RT Journal Article
T1 A quantitative biophysical principle to explain the 3D cellular connectivity in curved epithelia.
A1 Gomez-Galvez, Pedro
A1 Vicente-Munuera, Pablo
A1 Anbari, Samira
A1 Tagua, Antonio
A1 Gordillo-Vazquez, Carmen
A1 Andres-San Roman, Jesus A
A1 Franco-Barranco, Daniel
A1 Palacios, Ana M
A1 Velasco, Antonio
A1 Capitan-Agudo, Carlos
A1 Grima, Clara
A1 Annese, Valentina
A1 Arganda-Carreras, Ignacio
A1 Robles, Rafael
A1 Marquez, Alberto
A1 Buceta, Javier
A1 Escudero, Luis M
K1 bioimage analysis
K1 computational geometry
K1 developmental systems biology
K1 mathematical/biophysical modeling
K1 tissue/cellular biophysics
AB Epithelial cell organization and the mechanical stability of tissues are closely related. In this context, it has been recently shown that packing optimization in bended or folded epithelia is achieved by an energy minimization mechanism that leads to a complex cellular shape: the "scutoid". Here, we focus on the relationship between this shape and the connectivity between cells. We use a combination of computational, experimental, and biophysical approaches to examine how energy drivers affect the three-dimensional (3D) packing of tubular epithelia. We propose an energy-based stochastic model that explains the 3D cellular connectivity. Then, we challenge it by experimentally reducing the cell adhesion. As a result, we observed an increment in the appearance of scutoids that correlated with a decrease in the energy barrier necessary to connect with new cells. We conclude that tubular epithelia satisfy a quantitative biophysical principle that links tissue geometry and energetics with the average cellular connectivity.
PB Cell Press
YR 2022
FD 2022-07-13
LK http://hdl.handle.net/10668/22079
UL http://hdl.handle.net/10668/22079
LA en
NO Gómez-Gálvez P, Vicente-Munuera P, Anbari S, Tagua A, Gordillo-Vázquez C, Andrés-San Román JA, et al. A quantitative biophysical principle to explain the 3D cellular connectivity in curved epithelia. Cell Syst. 2022 Aug 17;13(8):631-643.e8.
DS RISalud
RD Apr 9, 2025