RT Journal Article T1 [Management of hyperglycaemia with non-insulin drugs in adult patients with type 2 diabetes]. T2 Manejo de la hiperglucemia con fármacos no insulínicos en pacientes adultos con diabetes tipo 2. A1 Álvarez-Guisasola, Fernando A1 Orozco-Beltrán, Domingo A1 Cebrián-Cuenca, Ana M A1 Ruiz Quintero, Manuel Antonio A1 Angullo Martínez, Escarlata A1 Ávila Lachica, Luis A1 Ortega Millán, Carlos A1 Caride Miana, Elena A1 Navarro-Pérez, Jorge A1 Sagredo Perez, Julio A1 Barrot de la Puente, Joan A1 Cos Claramunt, Francesc Xavier K1 Antidiabetic drugs K1 Diabetes tipo 2 K1 Fármacos antidiabéticos K1 Hiperglucemia K1 Hyperglycemia K1 Type 2 diabetes AB Treatment of diabetes mellitus type2 (DM2) includes healthy eating and exercise (150minutes/week) as basic pillars. For pharmacological treatment, metformin is the initial drug except contraindication or intolerance; in case of poor control, 8 therapeutic families are available (6 oral and 2 injectable) as possible combinations. An algorithm and some recommendations for the treatment of DM2 are presented. In secondary cardiovascular prevention, it is recommended to associate an inhibitor of the sodium-glucose cotransporter type 2 (iSGLT2) or a glucagon-like peptide-1 receptor agonist (arGLP1) in patients with obesity. In primary prevention if the patient is obese or overweight metformin should be combined with iSGLT2, arGLP1, or inhibitors of type4 dipeptidylpeptidase (iDPP4). If the patient does not present obesity, iDPP4, iSGLT2 or gliclazide, sulfonylurea, recommended due to its lower tendency to hypoglycaemia, may be used. YR 2019 FD 2019-07-15 LK http://hdl.handle.net/10668/14259 UL http://hdl.handle.net/10668/14259 LA es DS RISalud RD Apr 6, 2025