RT Journal Article
T1 Hypoxia in the Initiation and Progression of Neuroblastoma Tumours
A1 Huertas-Castaño, Carlos
A1 Gómez-Muñoz, María A.
A1 Pardal, Ricardo
A1 Vega, Francisco M.
K1 Neuroblastoma
K1 Hypoxia
K1 Neural crest cells
K1 Cancer stem cells
K1 Paediatric oncology
K1 Hipoxia
K1 Cresta neural
K1 Células madre neoplásicas
K1 Oncología médica
K1 Pediatría
K1 Hipoxia tumoral
AB Neuroblastoma is the most frequent extracranial solid tumour in children, causing 10% of all paediatric oncology deaths. It arises in the embryonic neural crest due to an uncontrolled behaviour of sympathetic nervous system progenitors, giving rise to heterogeneous tumours. Low local or systemic tissue oxygen concentration has emerged as a cellular stimulus with important consequences for tumour initiation, evolution and progression. In neuroblastoma, several evidences point towards a role of hypoxia in tumour initiation during development, tumour cell differentiation, survival and metastatic spreading. However, the heterogeneous nature of the disease, its developmental origin and the lack of suitable experimental models have complicated a clear understanding of the effect of hypoxia in neuroblastoma tumour progression and the molecular mechanisms implicated. In this review, we have compiled available evidences to try to shed light onto this important field. In particular, we explore the effect of hypoxia in neuroblastoma cell transformation and differentiation. We also discuss the experimental models available and the emerging alternatives to study this problem, and we present hypoxia-related therapeutic avenues being explored in the field.
PB MDPI
YR 2019
FD 2019-12-19
LK http://hdl.handle.net/10668/3768
UL http://hdl.handle.net/10668/3768
LA en
NO Huertas-Castaño C, Gómez-Muñoz MA, Pardal R, Vega FM. Hypoxia in the Initiation and Progression of Neuroblastoma Tumours. Int J Mol Sci. 2019 Dec 19;21(1):39
DS RISalud
RD Apr 6, 2025