RT Journal Article
T1 Nephroprotective Effect of the Virgin Olive Oil Polyphenol Hydroxytyrosol in Type 1-like Experimental Diabetes Mellitus: Relationships with Its Antioxidant Effect
A1 Rodríguez-Pérez, María Dolores
A1 López-Villodres, Juan Antonio
A1 Arrebola, María Monsalud
A1 Martín-Aurioles, Esther
A1 Fernández-Prior, África
A1 Bermúdez-Oria, Alejandra
A1 Ríos, María Carmen
A1 De La Cruz, José Pedro
A1 González-Correa, José Antonio
K1 Hydroxytyrosol
K1 Diabetes
K1 Nephropathy
K1 Virgin olive oil
K1 Diabetes mellitus
K1 Creatinine
K1 Oxidative stress
K1 Proteinuria
K1 Thromboxane
K1 Eicosanoids
K1 Nefropatías diabéticas
K1 Aceite de oliva
K1 Creatinina
K1 Estrés oxidativo
K1 Tromboxanos
K1 Eicosanoides
AB The aim of this study was to determine whether hydroxytyrosol administration prevented kidney damage in an experimental model of type 1 diabetes mellitus in rats. Hydroxytyrosol was administered to streptozotocin-diabetic rats: 1 and 5 mg/kg/day p.o. for two months. After hydroxytyrosol administration, proteinuria was significantly reduced (67-73%), calculated creatinine clearance was significantly increased (26-38%), and the glomerular volume and glomerulosclerosis index were decreased (20-30%). Hydroxytyrosol reduced oxidative and nitrosative stress variables and thromboxane metabolite production. Statistical correlations were found between biochemical and kidney function variables. Oral administration of 1 and 5 mg/kg/day of hydroxytyrosol produced an antioxidant and nephroprotective effect in an experimental model of type 1-like diabetes mellitus. The nephroprotective effect was significantly associated with the systemic and renal antioxidant action of hydroxytyrosol, which also influenced eicosanoid production.
PB MDPI
YR 2021
FD 2021-11-08
LK http://hdl.handle.net/10668/4338
UL http://hdl.handle.net/10668/4338
LA en
NO Rodríguez-Pérez MD, López-Villodres JA, Arrebola MM, Martín-Aurioles E, Fernández-Prior Á, Bermúdez-Oria A, et al. Nephroprotective Effect of the Virgin Olive Oil Polyphenol Hydroxytyrosol in Type 1-like Experimental Diabetes Mellitus: Relationships with Its Antioxidant Effect. Antioxidants. 2021 Nov 8;10(11):1783
DS RISalud
RD Apr 14, 2025