RT Journal Article
T1 Early Tuberculin Skin Test for the Diagnosis of Latent Tuberculosis Infection in Patients with Inflammatory Bowel Disease.
A1 Taxonera, Carlos
A1 Ponferrada, Angel
A1 Bermejo, Fernando
A1 Riestra, Sabino
A1 Saro, Cristina
A1 Martin-Arranz, Maria Dolores
A1 Cabriada, Jose Luis
A1 Barreiro-de Acosta, Manuel
A1 de Castro, Maria Luisa
A1 Lopez-Serrano, Pilar
A1 Barrio, Jesus
A1 Suarez, Cristina
A1 Iglesias, Eva
A1 Argüelles-Arias, Federico
A1 Ferrer, Isabel
A1 Marin-Jimenez, Ignacio
A1 Hernandez-Camba, Alejandro
A1 Bastida, Guillermo
A1 Van Domselaar, Manuel
A1 Martinez-Montiel, Pilar
A1 Olivares, David
A1 Alba, Cristina
A1 Gisbert, Javier P
K1 Crohn′s disease
K1 Tuberculosis
K1 Anti-TNF
K1 Immunosuppressant
K1 Inflammatory bowel disease
K1 Steroid
K1 Tuberculin skin test
K1 Ulcerative colitis
AB Sensitivity of tuberculin skin test [TST] during screening for latent tuberculosis infection [LTBI] is affected by steroid and/or immunosuppressant therapy. The aim of this study was to compare performance of the two-step TST in inflammatory bowel disease patients immediately before anti-tumour necrosis factor [TNF] therapy as part of routine screening for LTBI vs control patients when the TST was carried out at an early stage. In this multicentre prospective controlled study, we evaluated the performance of two-step TST with 5-mm threshold. Factors associated with TST results were determined by logistic regression. We evaluated 243 candidates for anti-TNF therapy and 337 control patients. Overall, 105 patients [18.1%] had an induration ≥ 5 mm in the first TST or in TST retest. LTBI was diagnosed in 25% of patients by TST retest. Twenty-eight [11.5%] anti-TNF group patients vs 77 [22.8%] control patients had a positive TST (odds ratio [OR] 0.44, 95% confidence interval [CI] 0.28-0.70; P  The sensitivity of routine TST performed just before starting anti-TNF therapy is low. TST performed at an early stage enables screening in the absence of immunosuppressive treatment and thus maximises the diagnostic yield of TST for detecting LTBI.
PB Oxford University Press
YR 2017
FD 2017-02-17
LK http://hdl.handle.net/10668/10990
UL http://hdl.handle.net/10668/10990
LA en
NO Taxonera C, Ponferrada Á, Bermejo F, Riestra S, Saro C, Martín-Arranz MD, et al.  Early Tuberculin Skin Test for the Diagnosis of Latent Tuberculosis Infection in Patients with Inflammatory Bowel Disease. J Crohns Colitis. 2017 Jul 1;11(7):792-800
DS RISalud
RD Aug 6, 2025