RT Journal Article
T1 Plasma Vitamin C and Type 2 Diabetes: Genome-Wide Association Study and Mendelian Randomization Analysis in European Populations.
A1 Zheng, Ju-Sheng
A1 Luan, Jian'an
A1 Sofianopoulou, Eleni
A1 Imamura, Fumiaki
A1 Stewart, Isobel D
A1 Day, Felix R
A1 Pietzner, Maik
A1 Wheeler, Eleanor
A1 Lotta, Luca A
A1 Gundersen, Thomas E
A1 Amiano, Pilar
A1 Ardanaz, Eva
A1 Chirlaque, María-Dolores
A1 Fagherazzi, Guy
A1 Franks, Paul W
A1 Kaaks, Rudolf
A1 Laouali, Nasser
A1 Mancini, Francesca Romana
A1 Nilsson, Peter M
A1 Onland-Moret, N Charlotte
A1 Olsen, Anja
A1 Overvad, Kim
A1 Panico, Salvatore
A1 Palli, Domenico
A1 Ricceri, Fulvio
A1 Rolandsson, Olov
A1 Spijkerman, Annemieke M W
A1 Sanchez-Perez, Maria-Jose
A1 Schulze, Matthias B
A1 Sala, Núria
A1 Sieri, Sabina
A1 Tjønneland, Anne
A1 Tumino, Rosario
A1 van der Schouw, Yvonne T
A1 Weiderpass, Elisabete
A1 Riboli, Elio
A1 Danesh, John
A1 Butterworth, Adam S
A1 Sharp, Stephen J
A1 Langenberg, Claudia
A1 Forouhi, Nita G
A1 Wareham, Nicholas J
AB Higher plasma vitamin C levels are associated with lower type 2 diabetes risk, but whether this association is causal is uncertain. To investigate this, we studied the association of genetically predicted plasma vitamin C with type 2 diabetes. We conducted genome-wide association studies of plasma vitamin C among 52,018 individuals of European ancestry to discover novel genetic variants. We performed Mendelian randomization analyses to estimate the association of genetically predicted differences in plasma vitamin C with type 2 diabetes in up to 80,983 case participants and 842,909 noncase participants. We compared this estimate with the observational association between plasma vitamin C and incident type 2 diabetes, including 8,133 case participants and 11,073 noncase participants. We identified 11 genomic regions associated with plasma vitamin C (P  These findings indicate discordance between biochemically measured and genetically predicted plasma vitamin C levels in the association with type 2 diabetes among European populations. The null Mendelian randomization findings provide no strong evidence to suggest the use of vitamin C supplementation for type 2 diabetes prevention.
YR 2020
FD 2020-11-17
LK http://hdl.handle.net/10668/16625
UL http://hdl.handle.net/10668/16625
LA en
DS RISalud
RD Apr 6, 2025