%0 Journal Article
%A Zheng, Ju-Sheng
%A Luan, Jian'an
%A Sofianopoulou, Eleni
%A Imamura, Fumiaki
%A Stewart, Isobel D
%A Day, Felix R
%A Pietzner, Maik
%A Wheeler, Eleanor
%A Lotta, Luca A
%A Gundersen, Thomas E
%A Amiano, Pilar
%A Ardanaz, Eva
%A Chirlaque, María-Dolores
%A Fagherazzi, Guy
%A Franks, Paul W
%A Kaaks, Rudolf
%A Laouali, Nasser
%A Mancini, Francesca Romana
%A Nilsson, Peter M
%A Onland-Moret, N Charlotte
%A Olsen, Anja
%A Overvad, Kim
%A Panico, Salvatore
%A Palli, Domenico
%A Ricceri, Fulvio
%A Rolandsson, Olov
%A Spijkerman, Annemieke M W
%A Sanchez-Perez, Maria-Jose
%A Schulze, Matthias B
%A Sala, Núria
%A Sieri, Sabina
%A Tjønneland, Anne
%A Tumino, Rosario
%A van der Schouw, Yvonne T
%A Weiderpass, Elisabete
%A Riboli, Elio
%A Danesh, John
%A Butterworth, Adam S
%A Sharp, Stephen J
%A Langenberg, Claudia
%A Forouhi, Nita G
%A Wareham, Nicholas J
%T Plasma Vitamin C and Type 2 Diabetes: Genome-Wide Association Study and Mendelian Randomization Analysis in European Populations.
%D 2020
%U http://hdl.handle.net/10668/16625
%X Higher plasma vitamin C levels are associated with lower type 2 diabetes risk, but whether this association is causal is uncertain. To investigate this, we studied the association of genetically predicted plasma vitamin C with type 2 diabetes. We conducted genome-wide association studies of plasma vitamin C among 52,018 individuals of European ancestry to discover novel genetic variants. We performed Mendelian randomization analyses to estimate the association of genetically predicted differences in plasma vitamin C with type 2 diabetes in up to 80,983 case participants and 842,909 noncase participants. We compared this estimate with the observational association between plasma vitamin C and incident type 2 diabetes, including 8,133 case participants and 11,073 noncase participants. We identified 11 genomic regions associated with plasma vitamin C (P  These findings indicate discordance between biochemically measured and genetically predicted plasma vitamin C levels in the association with type 2 diabetes among European populations. The null Mendelian randomization findings provide no strong evidence to suggest the use of vitamin C supplementation for type 2 diabetes prevention.
%~