RT Journal Article T1 Current Positioning against Severe Infections Due to Klebsiella pneumoniae in Hospitalized Adults. A1 Vidal-Cortes, Pablo A1 Martin-Loeches, Ignacio A1 Rodriguez, Alejandro A1 Bou, German A1 Cantón, Rafael A1 Diaz, Emili A1 De la Fuente, Carmen A1 Torre-Cisneros, Julian A1 Nuvials, Francisco Xavier A1 Salavert, Miguel A1 Aguilar, Gerardo A1 Nieto, Mercedes A1 Ramirez, Paula A1 Borges, Marcio A1 Soriano, Cruz A1 Ferrer, Ricard A1 Maseda, Emilio A1 Zaragoza, Rafael K1 ICU K1 KPC K1 Klebsiella pneumoniae K1 VAP K1 Carbapenemase-producing Enterobacterales (CPE) K1 Cefiderocol K1 Ceftazidime-avibactam K1 Imipenem-relebactam K1 Meropenem-vaborbactam K1 Nosocomial pneumonia AB Infections due to Klebsiella pneumoniae have been increasing in intensive care units (ICUs) in the last decade. Such infections pose a serious problem, especially when antimicrobial resistance is present. We created a task force of experts, including specialists in intensive care medicine, anaesthesia, microbiology and infectious diseases, selected on the basis of their varied experience in the field of nosocomial infections, who conducted a comprehensive review of the recently published literature on the management of carbapenemase-producing Enterobacterales (CPE) infections in the intensive care setting from 2012 to 2022 to summarize the best available treatment. The group established priorities regarding management, based on both the risk of developing infections caused by K. pneumoniae and the risk of poor outcome. Moreover, we reviewed and updated the most important clinical entities and the new antibiotic treatments recently developed. After analysis of the priorities outlined, this group of experts established a series of recommendations and designed a management algorithm. PB MDPI SN 2079-6382 YR 2022 FD 2022-08-25 LK http://hdl.handle.net/10668/20765 UL http://hdl.handle.net/10668/20765 LA en NO Vidal-Cortés P, Martin-Loeches I, Rodríguez A, Bou G, Cantón R, Diaz E, et al. Current Positioning against Severe Infections Due to Klebsiella pneumoniae in Hospitalized Adults. Antibiotics (Basel). 2022 Aug 27;11(9):1160 DS RISalud RD Apr 14, 2025