RT Journal Article T1 Off-label use of ketamine for treatment-resistant depression in clinical practice: European perspective. A1 López-Díaz, Álvaro A1 Murillo-Izquierdo, Manuel A1 Moreno-Mellado, Elisa K1 Treatment-resistant depression K1 antidepressants K1 ketamine AB Ketamine therapy for treatment-resistant depression in European national health systems may only be considered after attempting all evidence-based antidepressant strategies outlined in clinical guidelines. This paper seeks to explain the ethical, regulatory and procedural framework for the off-label use of ketamine for treatment-resistant depression within a public healthcare system.Declaration of interestNone. YR 2019 FD 2019-04-29 LK http://hdl.handle.net/10668/13886 UL http://hdl.handle.net/10668/13886 LA en DS RISalud RD Apr 10, 2025