RT Journal Article
T1 Evaluation of needle biopsy as a potential risk factor for local recurrence of Wilms tumour in the SIOP WT 2001 trial.
A1 Irtan, Sabine
A1 Van-Tinteren, Harm
A1 Graf, Norbert
A1 van-den-Heuvel-Eibrink, Marry M
A1 Heij, Hugo
A1 Bergeron, Christophe
A1 de-Camargo, Beatriz
A1 Acha, Tomas
A1 Spreafico, Filippo
A1 Vujanic, Gordan
A1 Powis, Mark
A1 Okoye, Bruce
A1 Wilde, Jim
A1 Godzinski, Jan
A1 Pritchard-Jones, Kathy
K1 Biopsy
K1 Local relapse
K1 SIOP WT 2001
K1 Wilms tumour
AB The impact of biopsying Wilms tumour (WT) at diagnosis on assigning the tumour stage and recommended treatment remains controversial. To address this important question, we analysed the potential association of all types of biopsy with local recurrence in patients treated in the SIOP WT 2001 trial, where needle biopsy was permitted without 'upstaging' the tumour to stage III. Only open biopsy required treatment as stage III. Among 2971 patients with unilateral WT (stages I-IV), 420 relapsed (139 local). Risk factors for recurrence were analysed by Cox proportional hazard methods. Biopsy was performed in 969 of 2971 (33%) patients (64% cutting needle, 30% fine needle aspiration [FNA] and 6% open biopsy). Biopsied patients were older, with larger tumours and a greater proportion with high-risk histology. In multivariate analysis that included all factors associated with local recurrence in univariate analysis, only high-risk histology (hazard ratio [HR] = 2.32; 95% confidence interval [CI]: 1.58-3.42, p= This post hoc analysis provides some reassurance that needle biopsy is not an independent adverse factor for either local recurrence or survival after adjustment for all relevant risk factors. Needle biopsy should not be an automatic criterion to 'upstage' WT.
PB Elsevier
YR 2019
FD 2019-06-01
LK http://hdl.handle.net/10668/14075
UL http://hdl.handle.net/10668/14075
LA en
NO Irtan S, Van Tinteren H, Graf N, van den Heuvel-Eibrink MM, Heij H, Bergeron C, et al. Evaluation of needle biopsy as a potential risk factor for local recurrence of Wilms tumour in the SIOP WT 2001 trial. Eur J Cancer. 2019 Jul;116:13-20
DS RISalud
RD Sep 12, 2025