RT Journal Article
T1 Gut Microbiota Profile and Changes in Body Weight in Elderly Subjects with Overweight/Obesity and Metabolic Syndrome.
A1 Atzeni, Alessandro
A1 Galié, Serena
A1 Muralidharan, Jananee
A1 Babio, Nancy
A1 Tinahones, Francisco José
A1 Vioque, Jesús
A1 Corella, Dolores
A1 Castañer, Olga
A1 Vidal, Josep
A1 Moreno-Indias, Isabel
A1 Torres-Collado, Laura
A1 Fernández-Carrión, Rebeca
A1 Fitó, Montserrat
A1 Olbeyra, Romina
A1 Martínez-González, Miguel Angel
A1 Bulló, Monica
A1 Salas-Salvadó, Jordi
K1 16S sequencing
K1 BMI
K1 clinical trial
K1 gut microbiota
K1 obesity
K1 weight loss
AB Gut microbiota is essential for the development of obesity and related comorbidities. However, studies describing the association between specific bacteria and obesity or weight loss reported discordant results. The present observational study, conducted within the frame of the PREDIMED-Plus clinical trial, aims to assess the association between fecal microbiota, body composition and weight loss, in response to a 12-month lifestyle intervention in a subsample of 372 individuals (age 55-75) with overweight/obesity and metabolic syndrome. Participants were stratified by tertiles of baseline body mass index (BMI) and changes in body weight after 12-month intervention. General assessments, anthropometry and biochemical measurements, and stool samples were collected. 16S amplicon sequencing was performed on bacterial DNA extracted from stool samples and microbiota analyzed. Differential abundance analysis showed an enrichment of Prevotella 9, Lachnospiraceae UCG-001 and Bacteroides, associated with a higher weight loss after 12-month of follow-up, whereas in the cross-sectional analysis, Prevotella 2 and Bacteroides were enriched in the lowest tertile of baseline BMI. Our findings suggest that fecal microbiota plays an important role in the control of body weight, supporting specific genera as potential target in personalized nutrition for obesity management. A more in-depth taxonomic identification method and the need of metabolic information encourages to further investigation.
SN 2076-2607
YR 2021
FD 2021-02-10
LK http://hdl.handle.net/10668/17169
UL http://hdl.handle.net/10668/17169
LA en
DS RISalud
RD Apr 20, 2025