TY - JOUR AU - Vasilijevic, Jasmina AU - Zamarreño, Noelia AU - Oliveros, Juan Carlos AU - Rodriguez-Frandsen, Ariel AU - Gómez, Guillermo AU - Rodriguez, Guadalupe AU - Pérez-Ruiz, Mercedes AU - Rey, Sonia AU - Barba, Isabel AU - Pozo, Francisco AU - Casas, Inmaculada AU - Nieto, Amelia AU - Falcón, Ana PY - 2017 DO - 10.1371/journal.ppat.1006650 UR - http://hdl.handle.net/10668/11675 T2 - PLoS pathogens AB - Influenza A virus (IAV) infection can be severe or even lethal in toddlers, the elderly and patients with certain medical conditions. Infection of apparently healthy individuals nonetheless accounts for many severe disease cases and deaths, suggesting... LA - en KW - Adolescent KW - Adult KW - Animals KW - Child KW - Child, Preschool KW - Female KW - Genome, Viral KW - Humans KW - Influenza A Virus, H1N1 Subtype KW - Influenza A Virus, H5N1 Subtype KW - Influenza, Human KW - Male KW - Mice KW - Middle Aged KW - Orthomyxoviridae Infections KW - Virulence KW - Virus Replication KW - Young Adult TI - Reduced accumulation of defective viral genomes contributes to severe outcome in influenza virus infected patients. TY - research article VL - 13 ER -