RT Journal Article
T1 Follow-up care of 12 months of patients with bladder cancer in Spain: A multicenter prospective cohort study.
A1 Bonfill, Xavier
A1 Martinez-Zapata, Maria Jose
A1 Barrionuevo-Rosas, Leslie
A1 Vernooij, Robin Wm
A1 Sanchez-Perez, Maria-Jose
A1 Morales-Suarez-Varela, Maria
A1 De la Cruz, Javier
A1 Emparanza, Jose Ignacio
A1 Ferrer, Montserrat
A1 Pijoan, Jose Ignacio
A1 Palou, Joan
A1 Frances, Albert
A1 Madrid, Eva
A1 Coscia, Claudia
A1 Zamora, Javier
A1 EMPARO-CU study group, 
K1 bladder neoplasms
K1 cohort study
K1 male urogenital diseases
K1 multicenter study
K1 multivariable analysis
AB The therapeutic approach of bladder cancer strongly determines its prognosis. We describe the treatments and outcomes for a Spanish cohort of patients with bladder cancer for the first 12 months after diagnosis and identify the factors that influenced the decision to undergo the treatment received. We conducted a multicenter, prospective, cohort study including primary bladder cancer patients during the first 12 months after diagnosis. The clinical outcomes were performance status (ECOG), adverse events and any cause of mortality. We stratified the analysis by factors that might influence the treatments received. We conducted univariate and multivariable logistic regression models to assess which patient and tumor characteristics were associated with receiving adjuvant treatment in the subgroup of noninvasive bladder cancer patients. In total, 314 patients were included (85% men; 53.8% >70 years) in 7 tertiary Spanish hospitals; 82.2% had a noninvasive urothelial bladder cancer (NMIBC). Patients received mostly surgery plus adjuvant therapy (67.7%). BCG (32.8% patients) was the most frequently administered adjuvant therapy, followed by intravesical chemotherapy (17.8% patients) and radiotherapy (10.8%). The variability of administered treatments among hospitals was low. Patients with NMIBC were more likely to receive adjuvant therapy if they had a higher educational level, some comorbidities and a high-grade tumor. The number of fully active patients (ECOG 0) significantly decreased during the first year of follow-up from 58% to 36 % (OR: 2.41, 95%CI 1.82-3.20); at 12-month follow-up 10.8% patients had died from any cause. In conclusion, most of the patients had a NMIBC. Surgery alone or plus adjuvant therapy were the commonest curative options of bladder cancer. BCG therapy was the adjuvant therapy most frequently administered. Higher educational level, presence of comorbidities and a high-grade tumor were associated with adjuvant therapy. Patient performance status was worsening over time. Almost 1 of 10 patients died during the first year of follow-up.
PB Wolters Kluwer Health
YR 2022
FD 2022-09-15
LK http://hdl.handle.net/10668/19855
UL http://hdl.handle.net/10668/19855
LA en
NO Bonfill X, Martinez-Zapata MJ, Barrionuevo-Rosas L, Vernooij RW, Sánchez MJ, Morales-Suárez-Varela M, et al. Follow-up care of 12 months of patients with bladder cancer in Spain: A multicenter prospective cohort study. Medicine (Baltimore). 2022 Oct 21;101(42):e31175.
DS RISalud
RD Apr 19, 2025