%0 Journal Article
%A Serrano-Lorenzo, Pablo
%A Coya, Olga N
%A López-Jimenez, Ana
%A Blázquez, Alberto
%A Delmiro, Aitor
%A Lucia, Alejandro
%A Arenas, Joaquín
%A Martín, Miguel A
%A COVID-19 ’12 Octubre’ Hospital Clinical Biochemistry Study Group
%T Plasma LDH: A specific biomarker for lung affectation in COVID-19?
%D 2021
%@ 2352-5517
%U https://hdl.handle.net/10668/25375
%X We aimed to determine whether the plasma profile of lactate dehydrogenase (LDH) isoenzymes is altered in patients with COVID-19, and whether this is attributable to a specific release of LDH-3, the main LDH isoenzyme expressed in lungs. We collected fresh plasma aliquots from 17 patients (LDH range, 281-822 U/L) and seven controls (LDH ​ Despite the expected higher total LDH activity levels in patients (p ​ ​0.05). We found no correlation between total plasma LDH activity and the in-gel relative activities of the different LDH isoenzymes, including LDH-3. Likewise, there was no correlation between LDH-3 and various routine haematological and serum parameters that have been previously reported to be altered in COVID-19 (such as lymphocyte count, albumin, alanine and aspartate aminotransferase, creatinine, C-reactive protein, or ferritin). Our findings suggest that elevation of plasma LDH activity in patients with COVID-19 is not associated to a specific release of LDH-3 into the bloodstream, and do not support the use of LDH as a specific biomarker for lung affectation in patients with COVID-19.
%K COVID-19
%K LDH isoenzymes
%K Lactate dehydrogenase
%K SARS-CoV-2
%~