RT Journal Article
T1 Evaluation of the immunogenicity and efficacy of BCG and MTBVAC vaccines using a natural transmission model of tuberculosis
A1 Roy, Alvaro
A1 Tomé, Irene
A1 Romero, Beatriz
A1 Lorente-Leal, Víctor
A1 Infantes-Lorenzo, José A
A1 Domínguez, Mercedes
A1 Martín, Carlos
A1 Aguiló, Nacho
A1 Puentes, Eugenia
A1 Rodríguez, Esteban
A1 de Juan, Lucía
A1 Risalde, María A
A1 Gortázar, Christian
A1 Domínguez, Lucas
A1 Bezos, Javier
K1 BCG Vaccine
K1 Vacuna BCG
K1 Mycobacterium tuberculosis
K1 Tuberculosis
K1 Mycobacterium bovis
K1 Infecciones por mycobacterium
K1 Mycobacterium infections
K1 Bacterial vaccines
K1 Vacunas bacterianas
K1 Natural transmission
K1 Transmisión natural
K1 Goats
K1 Cabra
K1 Animals
K1 Humans
AB Effective vaccines against tuberculosis (TB) are needed in order to prevent TB transmission in human and animal populations. Evaluation of TB vaccines may be facilitated by using reliable animal models that mimic host pathophysiology and natural transmission of the disease as closely as possible. In this study, we evaluated the immunogenicity and efficacy of two attenuated vaccines, BCG and MTBVAC, after each was given to 17 goats (2 months old) and then exposed for 9 months to goats infected with M. caprae. In general, MTBVAC-vaccinated goats showed higher interferon-gamma release than BCG vaccinated goats in response to bovine protein purified derivative and ESAT-6/CFP-10 antigens and the response was significantly higher than that observed in the control group until challenge. All animals showed lesions consistent with TB at the end of the study. Goats that received either vaccine showed significantly lower scores for pulmonary lymph nodes and total lesions than unvaccinated controls. Both MTBVAC and BCG vaccines proved to be immunogenic and effective in reducing severity of TB pathology caused by M. caprae. Our model system of natural TB transmission may be useful for evaluating and optimizing vaccines.
PB BioMed Central Ltd.
SN 0928-4249
YR 2019
FD 2019-10-15
LK http://hdl.handle.net/10668/3149
UL http://hdl.handle.net/10668/3149
LA en
NO Roy A, Tomé I, Romero B, Lorente-Leal V, Infantes-Lorenzo JA, Domínguez M, et al. Evaluation of the immunogenicity and efficacy of BCG and MTBVAC vaccines using a natural transmission model of tuberculosis. Vet Res. 2019  Oct 15;50:82.
DS RISalud
RD Apr 7, 2025