%0 Journal Article
%A Boot, Iris W A
%A Wesselius, Anke
%A Yu, Evan Y W
%A Brinkman, Maree
%A van den Brandt, Piet
%A Grant, Eric J
%A White, Emily
%A Weiderpass, Elisabete
%A Ferrari, Pietro
%A Schulze, Matthias B
%A Bueno-de-Mesquita, Bas
%A Jose-Sanchez, Maria
%A Gylling, Bjorn
%A Zeegers, Maurice P
%T Dietary B group vitamin intake and the bladder cancer risk: a pooled analysis of prospective cohort studies.
%D 2022
%U http://hdl.handle.net/10668/19897
%X Diet may play an essential role in the aetiology of bladder cancer (BC). The B group complex vitamins involve diverse biological functions that could be influential in cancer prevention. The aim of the present study was to investigate the association between various components of the B group vitamin complex and BC risk. Dietary data were pooled from four cohort studies. Food item intake was converted to daily intakes of B group vitamins and pooled multivariate hazard ratios (HRs), with corresponding 95% confidence intervals (CIs), were obtained using Cox-regression models. Dose-response relationships were examined using a nonparametric test for trend. In total, 2915 BC cases and 530,012 non-cases were included in the analyses. The present study showed an increased BC risk for moderate intake of vitamin B1 (HRB1: 1.13, 95% CI: 1.00-1.20). In men, moderate intake of the vitamins B1, B2, energy-related vitamins and high intake of vitamin B1 were associated with an increased BC risk (HR (95% CI): 1.13 (1.02-1.26), 1.14 (1.02-1.26), 1.13 (1.02-1.26; 1.13 (1.02-1.26), respectively). In women, high intake of all vitamins and vitamin combinations, except for the entire complex, showed an inverse association (HR (95% CI): 0.80 (0.67-0.97), 0.83 (0.70-1.00); 0.77 (0.63-0.93), 0.73 (0.61-0.88), 0.82 (0.68-0.99), 0.79 (0.66-0.95), 0.80 (0.66-0.96), 0.74 (0.62-0.89), 0.76 (0.63-0.92), respectively). Dose-response analyses showed an increased BC risk for higher intake of vitamin B1 and B12. Our findings highlight the importance of future research on the food sources of B group vitamins in the context of the overall and sex-stratified diet.
%K B group vitamins
%K Bladder cancer
%K Nutritional oncology
%K Pooled cohort analysis
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