RT Journal Article
T1 Approaching Shared Pathophysiology in Immune-Mediated Diseases through Functional Genomics
A1 González-Serna, David
A1 Villanueva-Martin, Gonzalo
A1 Acosta-Herrera, Marialbert
A1 Márquez, Ana
A1 Martín, Javier
K1 Functional genomics
K1 Immune-mediated diseases
K1 Trancriptomics
K1 GWAS
K1 Hi-C
K1 Shared genetics
K1 Genómica
K1 Inmunidad celular
K1 Estudio de asociación del genoma completo
K1 Genética
K1 Perfilación de la expresión génica
AB Immune-mediated diseases (IMDs) are complex pathologies that are strongly influenced by environmental and genetic factors. Associations between genetic loci and susceptibility to these diseases have been widely studied, and hundreds of risk variants have emerged during the last two decades, with researchers observing a shared genetic pattern among them. Nevertheless, the pathological mechanism behind these associations remains a challenge that has just started to be understood thanks to functional genomic approaches. Transcriptomics, regulatory elements, chromatin interactome, as well as the experimental characterization of genomic findings, constitute key elements in the emerging understandings of how genetics affects the etiopathogenesis of IMDs. In this review, we will focus on the latest advances in the field of functional genomics, centering our attention on systemic rheumatic IMDs.
PB MDPI
YR 2020
FD 2020-12-09
LK http://hdl.handle.net/10668/3731
UL http://hdl.handle.net/10668/3731
LA en
NO González-Serna D, Villanueva-Martin G, Acosta-Herrera M, Márquez A, Martín J. Approaching Shared Pathophysiology in Immune-Mediated Diseases through Functional Genomics. Genes. 2020 Dec 9;11(12):1482
DS RISalud
RD Apr 17, 2025