TY  - JOUR
AU  - Sot, Begoña
AU  - Rubio-Muñoz, Alejandra
AU  - Leal-Quintero, Ahudrey
AU  - Martínez-Sabando, Javier
AU  - Marcilla, Miguel
AU  - Roodveldt, Cintia
AU  - Valpuesta, José M
PY  - 2017
DO  - 10.1038/srep40859
UR  - http://hdl.handle.net/10668/10787
T2  - Scientific reports
AB  - The eukaryotic chaperonin CCT (chaperonin containing TCP-1) uses cavities built into its double-ring structure to encapsulate and to assist folding of a large subset of proteins. CCT can inhibit amyloid fibre assembly and toxicity of the polyQ...
LA  - en
KW  - Amyloid
KW  - Cell Line, Tumor
KW  - Chaperonin Containing TCP-1
KW  - Humans
KW  - Microscopy, Electron, Transmission
KW  - Mutagenesis, Site-Directed
KW  - Neurons
KW  - Protein Binding
KW  - Protein Multimerization
KW  - Protein Structure, Quaternary
KW  - Protein Subunits
KW  - alpha-Synuclein
TI  - The chaperonin CCT inhibits assembly of α-synuclein amyloid fibrils by a specific, conformation-dependent interaction.
TY  - research article
VL  - 7
ER  -