RT Journal Article
T1 Methodology of a Large Multicenter Observational Study of Patients with COVID-19 in Spanish Intensive Care Units.
A1 Torres, Antoni
A1 Motos, Anna
A1 Ceccato, Adrian
A1 Bermejo-Martin, Jesus
A1 de Gonzalo-Calvo, David
A1 Perez, Raquel
A1 Barroso, Marta
A1 Pascual, Ion Zubizarreta
A1 Gonzalez, Jessica
A1 Fernandez-Barat, Laia
A1 Ferrer, Ricard
A1 Riera, Jordi
A1 Garcia-Gasulla, Dario
A1 Peñuelas, Oscar
A1 Lorente, Jose Angel
A1 Almansa, Raquel
A1 Menendez, Rosario
A1 Kiarostami, Kasra
A1 Canseco, Joan
A1 Villar, Rosario Amaya
A1 Añon, Jose M
A1 Mariño, Ana Balan
A1 Barbera, Carme
A1 Barberan, Jose
A1 Ortiz, Aaron Blandino
A1 Boado, Maria Victoria
A1 Bustamante-Munguira, Elena
A1 Caballero, Jesus
A1 Canton-Bulnes, Maria Luisa
A1 Perez, Cristina Carbajales
A1 Carbonell, Nieves
A1 Catalan-Gonzalez, Mercedes
A1 de Frutos, Raul
A1 Franco, Nieves
A1 Galban, Cristobal
A1 Gumucio-Sanguino, Victor D
A1 Torre, Maria Del Carmen de la
A1 Diaz, Emili
A1 Estella, Angel
A1 Gallego, Elena
A1 Garmendia, Jose Luis Garcia
A1 Gomez, Jose M
A1 Huerta, Arturo
A1 Garcia, Ruth Noemi Jorge
A1 Loza-Vazquez, Ana
A1 Marin-Corral, Judith
A1 Delgado, Maria Cruz Martin
A1 Martinez de la Gandara, Amalia
A1 Varela, Ignacio Martinez
A1 Messa, Juan Lopez
A1 Albaiceta, Guillermo M
A1 Nieto, Maite
A1 Novo, Mariana Andrea
A1 Peñasco, Yhivian
A1 Perez-Garcia, Felipe
A1 Pozo-Laderas, Juan Carlos
A1 Ricart, Pilar
A1 Sagredo, Victor
A1 Sanchez-Miralles, Angel
A1 Chinesta, Susana Sancho
A1 Serra-Fortuny, Mireia
A1 Socias, Lorenzo
A1 Sole-Violan, Jordi
A1 Suarez-Sipmann, Fernando
A1 Lomas, Luis Tamayo
A1 Trenado, Jose
A1 Ubeda, Alejandro
A1 Valdivia, Luis Jorge
A1 Vidal, Pablo
A1 Barbe, Ferran
K1 Biomarcadores
K1 Biomarkers
K1 COVID-19
K1 Data management
K1 Estudios observacionales
K1 Follow-up
K1 Gestión de datos
K1 ICU
K1 Observational studies
K1 Seguimiento
K1 UCI
K1 Área de Gestión Sanitaria Campo de Gibraltar Oeste
K1 Área de Gestión Sanitaria de Jerez, Costa Noroeste y Sierra de Cádiz
K1 Área de Gestión Sanitaria Sur de Sevilla
AB The COVID-19 pandemic created tremendous challenges for health-care systems. Intensive care units (ICU) were hit with a large volume of patients requiring ICU admission, mechanical ventilation, and other organ support with very high mortality. The Centro de Investigación Biomédica en Red-Enfermedades Respiratorias (CIBERES), a network of Spanish researchers to investigate in respiratory disease, commissioned the current proposal in response to the Instituto de Salud Carlos III (ISCIII) call. CIBERESUCICOVID is a multicenter, observational, prospective/retrospective cohort study of patients with COVID-19 admitted to Spanish ICUs. Several work packages were created, including study population and ICU data collection, follow-up, biomarkers and miRNAs, data management and quality. This study included 6102 consecutive patients admitted to 55 ICUs homogeneously distributed throughout Spain and the collection of blood samples from more than 1000 patients. We enrolled a large population of COVID-19 ICU-admitted patients including baseline characteristics, ICU and MV data, treatments complications, and outcomes. The in-hospital mortality was 31%, and 76% of patients required invasive mechanical ventilation. A 3-6 month and 1 year follow-up was performed. Few deaths after 1 year discharge were registered. Low anti-SARS-CoV-2 S antibody levels predict mortality in critical COVID-19. These antibodies contribute to prevent systemic dissemination of SARS-CoV-2. The severity of COVID-19 impacts the circulating miRNA profile. Plasma miRNA profiling emerges as a useful tool for risk-based patient stratification in critically ill COVID-19 patients. We present the methodology used in a large multicenter study sponsored by ISCIII to determine the short- and long-term outcomes in patients with COVID-19 admitted to more than 50 Spanish ICUs.
PB Elsevier
YR 2022
FD 2022-03-30
LK http://hdl.handle.net/10668/22012
UL http://hdl.handle.net/10668/22012
LA en
LA es
NO Torres A, Motos A, Ceccato A, Bermejo-Martin J, de Gonzalo-Calvo D, Pérez R, et al. Methodology of a Large Multicenter Observational Study of Patients with COVID-19 in Spanish Intensive Care Units. Arch Bronconeumol. 2022 Apr;58 Suppl 1:22-31
DS RISalud
RD Apr 8, 2025