RT Journal Article
T1 Eradication of Hepatitis C Virus (HCV) Reduces Immune Activation, Microbial Translocation, and the HIV DNA Level in HIV/HCV-Coinfected Patients.
A1 Lopez-Cortes, Luis F
A1 Trujillo-Rodriguez, Maria
A1 Baez-Palomo, Alicia
A1 Benmarzouk-Hidalgo, Omar J
A1 Dominguez-Molina, Beatriz
A1 Milanes-Guisado, Yusnelkis
A1 Espinosa, Nuria
A1 Viciana, Pompeyo
A1 Gutierrez-Valencia, Alicia
K1 Bacterial Translocation
K1 Antiviral Agents
K1 HIV
K1 Humans
K1 Prospective Studies
K1 Sustained Virologic Response
K1 Treatment Outcome
K1 Viral Load
AB There are contradictory data about the influence that hepatitis C virus (HCV) has on immune activation and inflammation in patients coinfected with human immunodeficiency virus (HIV) and HCV. HIV/HCV-coinfected patients receiving antiretroviral treatment who achieved a sustained virological response with interferon-free regimens were consecutively enrolled in a prospective study. The following factors were assessed before, immediately after the end of, and 1 month after the end of therapy: expression of HLA-DR/CD38, PD-1, and CD57 on CD4+ and CD8+ T-cells; measurement of the total HIV DNA load in peripheral blood mononuclear cells; and determination of plasma levels of soluble CD14 (sCD14), lipopolysaccharide (LPS), 16S ribosomal DNA (rDNA), interleukin 6 (IL-6), D-dimers, and high-sensitivity C-reactive protein (hsCRP). Ninety-seven patients were consecutively included. At the end of therapy and 1 month later, there were significant reductions in the expression of HLA-DR and CD38 in CD4+ and CD8+ T cells, as well as levels of proviral HIV DNA, sCD14, LPS, 16S rDNA, and D-dimer (P  HCV eradication in HIV/HCV-coinfected patients results in significant decreases in levels of immune activation markers, proviral HIV DNA load, microbial translocation markers, and D-dimers. These findings support the use of HCV treatment for all HIV/HCV-coinfected patients, even those with low-grade fibrosis.
PB Oxford University Press
YR 2018
FD 2018-08-15
LK http://hdl.handle.net/10668/12696
UL http://hdl.handle.net/10668/12696
LA en
NO López-Cortés LF, Trujillo-Rodríguez M, Báez-Palomo A, Benmarzouk-Hidalgo OJ, Dominguez-Molina B, Milanés-Guisado Y, et al. Eradication of Hepatitis C Virus (HCV) Reduces Immune Activation, Microbial Translocation, and the HIV DNA Level in HIV/HCV-Coinfected Patients. J Infect Dis. 2018 Jul 13;218(4):624-632.
DS RISalud
RD Aug 13, 2025