%0 Journal Article
%A Camarillo, Rosa
%A Jimeno, Sonia
%A Huertas, Pablo
%T The Effect of Atypical Nucleic Acids Structures in DNA Double Strand Break Repair: A Tale of R-loops and G-Quadruplexes
%D 2021
%U http://hdl.handle.net/10668/4085
%X The fine tuning of the DNA double strand break repair pathway choice relies on different regulatory layers that respond to environmental and local cues. Among them, the presence of non-canonical nucleic acids structures seems to create challenges for the repair of nearby DNA double strand breaks. In this review, we focus on the recently published effects of G-quadruplexes and R-loops on DNA end resection and homologous recombination. Finally, we hypothesized a connection between those two atypical DNA structures in inhibiting the DNA end resection step of HR.
%K R-loops
%K DNA double strand break repair
%K Homologous recombination (HR)
%K DNA end resection
%K G-quadruplex
%K Estructuras R-loop
%K Recombinación homóloga
%K G-cuádruplex
%K ADN
%K ARN
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