RT Journal Article
T1 Inflammatory profile of incident cases of late-onset compared with young-onset rheumatoid arthritis: A nested cohort study.
A1 Mena-Vazquez, Natalia
A1 Lisbona-Montañez, Jose Manuel
A1 Redondo-Rodriguez, Rocio
A1 Mucientes, Arkaitz
A1 Manrique-Arija, Sara
A1 Rioja, Jose
A1 Garcia-Studer, Aimara
A1 Ortiz-Marquez, Fernando
A1 Cano-Garcia, Laura
A1 Fernandez-Nebro, Antonio
K1 Aging
K1 Early rheumatoid arthritis
K1 Inflammation
K1 Late-onset rheumatoid arthritis
K1 Young-onset rheumatoid arthritis
AB To describe the characteristics of patients between late-onset rheumatoid arthritis (LORA) with young-onset (YORA), and analyze their association with cumulative inflammatory burden. We performed a nested cohort study in a prospective cohort comprising 110 patients with rheumatoid arthritis (RA) and 110 age- and sex-matched controls. The main variable was cumulative inflammatory activity according to the 28-joint Disease Activity Score with erythrocyte sedimentation rate (DAS28-ESR). High activity was defined as DAS28 ≥ 3.2 and low activity as DAS28  A total of 22/110 patients (20%) met the criteria for LORA (≥ 60 years). Patients with LORA more frequently had comorbid conditions than patients with YORA and controls. Compared with YORA patients, more LORA patients had cumulative high inflammatory activity from onset [13 (59%) vs. 28 (31%); p = 0.018] and high values for CRP (p = 0.039) and IL-6 (p = 0.045). Cumulative high inflammatory activity in patients with RA was associated with LORA [OR (95% CI) 4.69 (1.49-10.71); p = 0.008], smoking [OR (95% CI) 2.07 (1.13-3.78); p = 0.017], anti-citrullinated peptide antibody [OR (95% CI) 3.24 (1.15-9.13); p = 0.025], average Health Assessment Questionnaire (HAQ) score [OR (95% CI) 2.09 (1.03-14.23); p = 0.034], and physical activity [OR (95% CI) 0.99 (0.99-0.99); p = 0.010]. The second model revealed similar associations with inflammatory activity in patients with LORA. Control of inflammation after diagnosis is poorer and comorbidity more frequent in patients with LORA than in YORA patients and healthy controls.
PB Frontiers Research Foundation
SN 2296-858X
YR 2022
FD 2022-11-08
LK http://hdl.handle.net/10668/20613
UL http://hdl.handle.net/10668/20613
LA en
NO Mena-Vázquez N, Lisbona-Montañez JM, Redondo-Rodriguez R, Mucientes A, Manrique-Arija S, Rioja J, et al. Inflammatory profile of incident cases of late-onset compared with young-onset rheumatoid arthritis: A nested cohort study. Front Med (Lausanne). 2022 Nov 8;9:1016159.
DS RISalud
RD Oct 29, 2025