RT Journal Article
T1 Clinical Outcomes after Surgical Resection Combined with Brachytherapy for Uveal Melanomas.
A1 Relimpio-López, Isabel
A1 Garrido-Hermosilla, Antonio Manuel
A1 Espejo, Francisco
A1 Gessa-Sorroche, María
A1 Coca, Lourdes
A1 Domínguez, Belen
A1 Díaz-Granda, María Jesús
A1 Ponte, Beatriz
A1 Cano, María José
A1 Rodríguez de la Rúa, Enrique
A1 Carrasco-Peña, Francisco
A1 Míguez, Carlos
A1 Saavedra, Jonathan
A1 Ontanilla, Antonio
A1 Caparrós-Escudero, Carlos
A1 Ríos, Juan José
A1 Terrón, José Antonio
K1 brachytherapy
K1 exoresection
K1 surgery
K1 uveal melanoma
AB Currently, brachytherapy is the most commonly used therapeutic approach for uveal melanomas. Surgical resection by means of endoresection or exoresection is an alternative approach. The present report recounts our experience over 15 years in the treatment of uveal melanoma using a combined approach of resection surgery with brachytherapy. This is a single-center observational retrospective cohort study in which we describe clinical outcomes, complications and survival in 35 cases of melanoma of the iris or the ciliary body after a combination of surgery and brachytherapy or brachytherapy alone. Local treatment of the tumor was successful in all cases with surgery and brachytherapy. The most frequent complications were scleromalacia, bullous keratopathy, retinal toxicity, cataracts, hypotonia, and photophobia. There were three cases of recurrence, all of which were found in the group of patients who had received brachytherapy alone, and in one case we had to perform a secondary enucleation due to tumor growth after brachytherapy. At present, only one patient has died during follow-up due to liver metastases six years after the start of treatment. In carefully selected patients, this approach can be effective and safe, as long as a close follow-up is carried out after surgery.
SN 2077-0383
YR 2022
FD 2022-03-15
LK http://hdl.handle.net/10668/21256
UL http://hdl.handle.net/10668/21256
LA en
DS RISalud
RD Sep 4, 2025