TY - JOUR AU - Gavito, Ana Luisa AU - Bautista, Dolores AU - Suarez, Juan AU - Badran, Samir AU - Arco, Rocío AU - Pavón, Francisco Javier AU - Serrano, Antonia AU - Rivera, Patricia AU - Decara, Juan AU - Cuesta, Antonio Luis AU - Rodríguez-de-Fonseca, Fernando AU - Baixeras, Elena PY - 2016 DO - 10.1371/journal.pone.0157956 UR - http://hdl.handle.net/10668/2399 T2 - PloS One AB - High-fat diet-induced obesity (DIO) is associated with fatty liver and elevated IL-6 circulating levels. IL-6 administration in rodents has yielded contradictory results regarding its effects on steatosis progression. In some models of fatty liver... LA - en PB - Public Libray of Science KW - Animales KW - Alimentación rica en grasa KW - Hígado graso KW - Glucosa KW - Humanos KW - Interleucina-6 KW - Leptina KW - Metabolismo lipídico KW - Lípidos KW - Lipogénesis KW - Ratones KW - Ratones consanguíneos C57BL KW - Ratones obesos KW - Obesidad KW - Ratas KW - Ratas Zucker KW - Receptores de interleucina-6 KW - Factor de necrosis tumoral alfa KW - Medical Subject Headings::Organisms::Eukaryota::Animals KW - Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet::Diet, High-Fat KW - Medical Subject Headings::Diseases::Digestive System Diseases::Liver Diseases::Fatty Liver KW - Medical Subject Headings::Chemicals and Drugs::Carbohydrates::Monosaccharides::Hexoses::Glucose KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans KW - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Intercellular Signaling Peptides and Proteins::Cytokines KW - Medical Subject Headings::Chemicals and Drugs::Biological Factors::Intercellular Signaling Peptides and Proteins::Adipokines::Leptin KW - Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Lipid Metabolism KW - Medical Subject Headings::Chemicals and Drugs::Lipids KW - Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Lipid Metabolism::Lipogenesis KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Animal Population Groups::Animals, Laboratory::Animals, Inbred Strains::Mice, Inbred Strains::Mice, Inbred C57BL KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice::Mice, Mutant Strains::Mice, Obese KW - Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Body Weight::Overweight::Obesity KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Rats KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Rats::Rats, Mutant Strains::Rats, Zucker KW - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, Immunologic::Receptors, Cytokine::Receptors, Interleukin::Receptors, Interleukin-6 KW - Medical Subject Headings::Chemicals and Drugs::Biological Factors::Intercellular Signaling Peptides and Proteins::Tumor Necrosis Factors::Tumor Necrosis Factor-alpha TI - Chronic IL-6 Administration Desensitizes IL-6 Response in Liver, Causes Hyperleptinemia and Aggravates Steatosis in Diet-Induced-Obese Mice. TY - research article ER -