RT Journal Article
T1 Chronic IL-6 Administration Desensitizes IL-6 Response in Liver, Causes Hyperleptinemia and Aggravates Steatosis in Diet-Induced-Obese Mice.
A1 Gavito, Ana Luisa
A1 Bautista, Dolores
A1 Suarez, Juan
A1 Badran, Samir
A1 Arco, Rocío
A1 Pavón, Francisco Javier
A1 Serrano, Antonia
A1 Rivera, Patricia
A1 Decara, Juan
A1 Cuesta, Antonio Luis
A1 Rodríguez-de-Fonseca, Fernando
A1 Baixeras, Elena
K1 Animales
K1 Alimentación rica en grasa
K1 Hígado graso
K1 Glucosa
K1 Humanos
K1 Interleucina-6
K1 Leptina
K1 Metabolismo lipídico
K1 Lípidos
K1 Lipogénesis
K1 Ratones
K1 Ratones consanguíneos C57BL
K1 Ratones obesos
K1 Obesidad
K1 Ratas
K1 Ratas Zucker
K1 Receptores de interleucina-6
K1 Factor de necrosis tumoral alfa
AB High-fat diet-induced obesity (DIO) is associated with fatty liver and elevated IL-6 circulating levels. IL-6 administration in rodents has yielded contradictory results regarding its effects on steatosis progression. In some models of fatty liver disease, high doses of human IL-6 ameliorate the liver steatosis, whereas restoration of IL-6 in DIO IL-6-/- mice up-regulates hepatic lipogenic enzymes and aggravates steatosis. We further examined the effects of chronic low doses of murine IL-6 on hepatic lipid metabolism in WT mice in DIO. IL-6 was delivered twice daily in C57BL/6J DIO mice for 15 days. The status and expression of IL-6-signalling mediators and targets were investigated in relation to the steatosis and lipid content in blood and in liver. IL-6 administration in DIO mice markedly raised circulating levels of lipids, glucose and leptin, elevated fat liver content and aggravated steatosis. Under IL-6 treatment there was hepatic Stat3 activation and increased gene expression of Socs3 and Tnf-alpha whereas the gene expression of endogenous IL-6, IL-6-receptor, Stat3, Cpt1 and the enzymes involved in lipogenesis was suppressed. These data further implicate IL-6 in fatty liver disease modulation in the context of DIO, and indicate that continuous stimulation with IL-6 attenuates the IL-6-receptor response, which is associated with high serum levels of leptin, glucose and lipids, the lowering levels of lipogenic and Cpt1 hepatic enzymes and with increased Tnf-alpha hepatic expression, a scenario evoking that observed in IL-6-/- mice exposed to DIO and in obese Zucker rats.
PB Public Libray of Science
YR 2016
FD 2016-06-22
LK http://hdl.handle.net/10668/2399
UL http://hdl.handle.net/10668/2399
LA en
NO Gavito AL, Bautista D, Suarez J, Badran S, Arco R, Pavón FJ, et al. Chronic IL-6 Administration Desensitizes IL-6 Response in Liver, Causes Hyperleptinemia and Aggravates Steatosis in Diet-Induced-Obese Mice. PLoS ONE. 2016; 11(6):e0157956
NO Journal Article;
DS RISalud
RD Apr 5, 2025