RT Journal Article
T1 Persistent HIV-controllers are more prone to spontaneously clear HCV: a retrospective cohort study.
A1 Dominguez-Molina, Beatriz
A1 Tarancon-Diez, Laura
A1 Milanés-Guisado, Yusnelkis
A1 Genebat, Miguel
A1 Resino, Salvador
A1 Rodriguez, Carmen
A1 Gonzalez-García, Juan
A1 Rallón, Norma
A1 Pernas, Maria
A1 Casado, Concepción
A1 Lopez-Galíndez, Cecilio
A1 León, Agathe
A1 Benito, Jose M
A1 García, Felipe
A1 Del Romero, Jorge
A1 Viciana, Pompeyo
A1 Lopez-Cortes, Luis F
A1 Leal, Manuel
A1 Ruiz-Mateos, Ezequiel
A1 ECRIS integrated in the Spanish AIDS Research Network, 
K1 HCV
K1 HCV spontaneous clearance
K1 HIV
K1 HIV-controllers
K1 persistent
K1 transient
AB HIV-controllers have the ability to spontaneously maintain viraemia at low or undetectable levels in the absence of antiretroviral treatment. Furthermore, HIV-controllers seem to have a superior capacity to spontaneously clear hepatitis C virus (HCV) compared to non HIV-controllers. Some of these subjects eventually lose HIV-controller status (transient controllers), whereas some HIV-controllers show a persistent natural HIV control (persistent controllers). We aimed to analyse whether persistent controllers have superior capacity to spontaneously clear HCV compared to transient controllers. We recruited HIV-controllers from January 1981 up to October 2016 with available antibodies to HCV (anti-HCV) data (n = 744). Factors associated with HIV spontaneous control in relation to HCV status were analysed in persistent and transient HIV-controllers with anti-HCV positive (n = 202 and n = 138 respectively) in comparison with 1700 HCV positive non HIV-controllers recruited from January 1981 up to March 2018, bivariate and multivariate analyses, following a logistic regression model, were applied. In addition, the factors related to the loss and time to lose HIV-controller status were explored (n = 744) using Log rank test and Kaplan-Meier curves, in this case the multivariate analysis consisted in a Cox regression model. A higher frequency of HCV spontaneous clearance was found in persistent HIV-controllers (25.5%) compared to non-controllers (10.2%). After adjusting for potential confounders, as sex, age, HIV transmission risk, CD4+ T-cell nadir and time of follow-up, HCV clearance was independently associated with persistent HIV spontaneous control (p = 0.002; OR (95% CI) = 2.573 (1.428 to 4.633)), but not with transient spontaneous control (p = 0.119; 1.589 (0.888 to 2.845)). Furthermore, persistent HIV-controllers were more likely to spontaneously clear the HCV in comparison with transient controllers (p = 0.027; 0.377 (0.159 to 0.893). Finally, not to lose or lengthen the time of losing this control was independently associated with HCV spontaneous clearance (p = 0.010; 0.503 (0.297 to 0.850). This study shows an association between spontaneous persistent HIV-control and HCV spontaneous clearance. The study findings support the idea of preserved immune mechanisms in persistent HIV control implicated in HCV spontaneous clearance. These results highlight persistent HIV-controllers but not transient controllers as a good model of functional HIV cure.
YR 2020
FD 2020
LK https://hdl.handle.net/10668/25489
UL https://hdl.handle.net/10668/25489
LA en
DS RISalud
RD Apr 17, 2025