RT Journal Article T1 May bioactive compounds from the olive fruit improve the postprandial insulin response in healthy adults? A1 Sanchez-Rodriguez, Estefania A1 Alejandra Vazquez-Aguilar, Laura A1 Biel-Glesson, Sara A1 Ramon Fernandez-Navarro, Jose A1 Antonio Espejo-Calvo, Juan A1 Maria Olmo-Peinado, Jose A1 de la Torre, Rafael A1 Fito-Colomer, Monserrat A1 Isabel Covas, Maria A1 Romero, Concepcion A1 Brenes, Manuel A1 Martinez de Victoria, Emilio A1 Gil, Angel A1 Dolores Mesa, Maria K1 Gastrointestinal hormones K1 Insulin sensitivity K1 Olive oil K1 Phenolic compounds K1 Triterpenic acids K1 Pentacyclic triterpenes K1 Glucose K1 Oil K1 Sensitivity K1 Ghrelin K1 Index AB Scope. The postprandial effects of virgin olive oils (VOOs) enriched with phenolic compounds and triterpenes from the olive fruit on plasma glucose and insulin (primary outcomes), and gastrointestinal hormones responses were evaluated in healthy adults. Methods and results: Single doses (30 mL) of three oils were evaluated: optimized polyphenols-rich VOO (OVOO); functional olive oil (FOO): OVOO enriched with triterpene acids; and VOO with low content of polyphenols. Postprandial plasma insulin release was lower after the intake of the FOO compared to VOO, while plasma glucose levels were lower after the intake of the VOO compared to OVOO. Matsuda's index of insulin sensitivity improved after the intake of FOO and OVOO, while the insulinogenic index and gastric inhibitory polypeptide (GIP) tended to improve after the intake of OVOO. Conclusion: The enrichment of VOOs with bioactive compounds from the olive fruit increases its benefits, improving postprandial insulin release and peripheral tissue sensitivity. PB Elsevier SN 1756-4646 YR 2021 FD 2021-05-27 LK http://hdl.handle.net/10668/18822 UL http://hdl.handle.net/10668/18822 LA en NO Estefania Sanchez-Rodriguez, Laura Alejandra Vazquez-Aguilar, Sara Biel-Glesson, Jose Ramon Fernandez-Navarro, Juan Antonio Espejo-Calvo, Jose Maria et al. May bioactive compounds from the olive fruit improve the ostprandial insulin response in healthy adults?, Journal of Functional Foods,Volume 83, 2021, 104561, DS RISalud RD Apr 7, 2025