RT Journal Article
T1 A Prospective Diet-Wide Association Study for Risk of Colorectal Cancer in EPIC.
A1 Papadimitriou, Nikos
A1 Bouras, Emmanouil
A1 van den Brandt, Piet A
A1 Muller, David C
A1 Papadopoulou, Areti
A1 Heath, Alicia K
A1 Critselis, Elena
A1 Gunter, Marc J
A1 Vineis, Paolo
A1 Ferrari, Pietro
A1 Weiderpass, Elisabete
A1 Boeing, Heiner
A1 Bastide, Nadia
A1 Merritt, Melissa A
A1 Lopez, David S
A1 Bergmann, Manuela M
A1 Perez-Cornago, Aurora
A1 Schulze, Matthias
A1 Skeie, Guri
A1 Srour, Bernard
A1 Eriksen, Anne Kirstine
A1 Boden, Stina
A1 Johansson, Ingegerd
A1 Nøst, Therese Haugdahl
A1 Lukic, Marco
A1 Ricceri, Fulvio
A1 Ericson, Ulrika
A1 Huerta, Jose Maria
A1 Dahm, Christina C
A1 Agnoli, Claudia
A1 Amiano, Pilar Exezarreta
A1 Tjønneland, Anne
A1 Gurrea, Aurelio Barricarte
A1 Bueno-de-Mesquita, Bas
A1 Ardanaz, Eva
A1 Berntsson, Jonna
A1 Sanchez-Perez, Maria-Jose
A1 Tumino, Rosario
A1 Panico, Salvatore
A1 Katzke, Verena
A1 Jakszyn, Paula
A1 Masala, Giovanna
A1 Derksen, Jeroen W G
A1 Quiros, J Ramon
A1 Severi, Gianluca
A1 Cross, Amanda J
A1 Riboli, Ellio
A1 Tzoulaki, Ioanna
A1 Tsilidis, Konstantinos K
K1 cohort study
K1 colorectal cancer
K1 epidemiology
K1 nutrition
AB This study is a comprehensive diet-wide association study (DWAS) aimed at identifying dietary factors associated with colorectal cancer (CRC) risk in a large cohort. Previous research on the link between diet and CRC risk has shown inconsistent results, so the goal of this study was to clarify the associations between several dietary exposures and CRC risk. The study assessed 92 food and nutrient intakes in 386,792 participants, 5,069 of whom developed incident CRC. Multiple comparisons were corrected for using the false discovery rate, and the findings were replicated in the Netherlands Cohort Study (NLCS). Additionally, the study examined gene-nutrient interactions based on known CRC-associated genetic loci. The results revealed 20 associations between dietary exposures and CRC risk. Some of the factors found to be positively associated with CRC risk included alcohol, liquor/spirits, wine, beer/cider, soft drinks, and pork. In contrast, milk, cheese, calcium, phosphorus, magnesium, potassium, riboflavin, vitamin B6, beta carotene, fruit, fiber, nonwhite bread, banana, and total protein intakes were inversely associated with CRC risk. Thirteen of these associations were replicated in the NLCS, and a meta-analysis of these replicated associations provided further insights. For example, alcohol, liquor/spirits, wine, and beer/cider were positively associated with CRC risk, whereas milk, cheese, and several nutrients such as calcium, phosphorus, magnesium, and riboflavin were inversely associated with the risk of developing CRC. However, no significant gene-nutrient interactions were found after adjusting for multiple comparisons. The findings from this study confirm the positive association between alcohol and CRC risk and suggest that higher intakes of dairy products, calcium, and certain nutrients may be protective against CRC.
PB Elsevier Inc.
YR 2021
FD 2021-04-24
LK http://hdl.handle.net/10668/22083
UL http://hdl.handle.net/10668/22083
LA en
NO Papadimitriou N, Bouras E, van den Brandt PA, Muller DC, Papadopoulou A, Heath AK, et al.  A Prospective Diet-Wide Association Study for Risk of Colorectal Cancer in EPIC. Clin Gastroenterol Hepatol. 2022 Apr;20(4):864-873.e13.
DS RISalud
RD Apr 7, 2025