TY  - JOUR
AU  - Ibáñez-Costa, Alejandro
AU  - López-Sánchez, Laura M
AU  - Gahete, Manuel D
AU  - Rivero-Cortés, Esther
AU  - Vázquez-Borrego, Mari C
AU  - Gálvez, María A
AU  - de la Riva, Andrés
AU  - Venegas-Moreno, Eva
AU  - Jiménez-Reina, Luis
AU  - Moreno-Carazo, Alberto
AU  - Tinahones, Francisco J
AU  - Maraver-Selfa, Silvia
AU  - Japón, Miguel A
AU  - García-Arnés, Juan A
AU  - Soto-Moreno, Alfonso
AU  - Webb, Susan M
AU  - Kineman, Rhonda D
AU  - Culler, Michael D
AU  - Castaño, Justo P
AU  - Luque, Raúl M
PY  - 2017
DO  - 10.1038/srep42002
UR  - http://hdl.handle.net/10668/2675
T2  - Scientific Reports
AB  - Chimeric somatostatin/dopamine compounds such as BIM-23A760, an sst2/sst5/D2 receptors-agonist, have emerged as promising new approaches to treat pituitary adenomas. However, information on direct in vitro effects of BIM-23A760 in normal and tumoral...
LA  - en
PB  - Nature Publishing Group
KW  - Adenoma hipofisario secretor de ACTH
KW  - Adenoma
KW  - Apoptosis
KW  - Supervivencia celular
KW  - Dopamina
KW  - Humanos
KW  - Hormonas hipofisarias
KW  - Neoplasias hipofisarias
KW  - Primates
KW  - Receptores dopaminérgicos
KW  - Receptores de somatostatina
KW  - Somatostatina
KW  - Medical Subject Headings::Diseases::Endocrine System Diseases::Endocrine Gland Neoplasms::Pituitary Neoplasms::ACTH-Secreting Pituitary Adenoma
KW  - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Death::Apoptosis
KW  - Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Glandular and Epithelial::Adenoma
KW  - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Survival
KW  - Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amines::Catecholamines::Dopamine
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
KW  - Medical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Pituitary Hormones
KW  - Medical Subject Headings::Diseases::Endocrine System Diseases::Pituitary Diseases::Pituitary Neoplasms
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, Neurotransmitter::Receptors, Biogenic Amine::Receptors, Catecholamine::Receptors, Dopamine
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, Neurotransmitter::Receptors, Neuropeptide::Receptors, Somatostatin
KW  - Medical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Hypothalamic Hormones::Pituitary Hormone Release Inhibiting Hormones::Somatostatin
TI  - BIM-23A760 influences key functional endpoints in pituitary adenomas and normal pituitaries: molecular mechanisms underlying the differential response in adenomas
TY  - research article
ER  -