TY  - JOUR
AU  - Salas-Armenteros, Irene
AU  - Pérez-Calero, Carmen
AU  - Bayona-Feliu, Aleix
AU  - Tumini, Emanuela
AU  - Luna, Rosa
AU  - Aguilera, Andrés
PY  - 2017
DO  - 10.15252/embj.201797208
UR  - http://hdl.handle.net/10668/11735
T2  - The EMBO journal
AB  - R-loops, formed by co-transcriptional DNA-RNA hybrids and a displaced DNA single strand (ssDNA), fulfill certain positive regulatory roles but are also a source of genomic instability. One key cellular mechanism to prevent R-loop accumulation centers...
LA  - en
KW  - DNA–RNA hybrids
KW  - Sin3A deacetylase
KW  - THO/TREX
KW  - genome instability
KW  - histone acetylation
KW  - Acetylation
KW  - Cell Cycle Proteins
KW  - DNA, Single-Stranded
KW  - DNA-Binding Proteins
KW  - Gene Knockdown Techniques
KW  - Genomic Instability
KW  - HEK293 Cells
KW  - HeLa Cells
KW  - Histones
KW  - Humans
KW  - Models, Biological
KW  - Nuclear Proteins
KW  - RNA
KW  - RNA Processing, Post-Transcriptional
KW  - RNA-Binding Proteins
KW  - Repressor Proteins
KW  - Sin3 Histone Deacetylase and Corepressor Complex
KW  - Transcription, Genetic
TI  - Human THO-Sin3A interaction reveals new mechanisms to prevent R-loops that cause genome instability.
TY  - research article
VL  - 36
ER  -