RT Journal Article
T1 Dietary intake of trans fatty acids and breast cancer risk in 9 European countries.
A1 Matta, Michele
A1 Huybrechts, Inge
A1 Biessy, Carine
A1 Casagrande, Corinne
A1 Yammine, Sahar
A1 Fournier, Agnes
A1 Olsen, Karina Standahl
A1 Lukic, Marco
A1 Gram, Inger Torhild
A1 Ardanaz, Eva
A1 Sanchez-Perez, Maria-Jose
A1 Dossus, Laure
A1 Fortner, Renee T
A1 Srour, Bernard
A1 Jannasch, Franziska
A1 Schulze, Matthias B
A1 Amiano, Pilar
A1 Agudo, Antonio
A1 Colorado-Yohar, Sandra
A1 Quirós, J Ramon
A1 Tumino, Rosario
A1 Panico, Salvatore
A1 Masala, Giovanna
A1 Pala, Valeria
A1 Sacerdote, Carlotta
A1 Tjønneland, Anne
A1 Olsen, Anja
A1 Dahm, Christina C
A1 Rosendahl, Ann H
A1 Borgquist, Signe
A1 Wennberg, Maria
A1 Heath, Alicia K
A1 Aune, Dagfinn
A1 Schmidt, Julie
A1 Weiderpass, Elisabete
A1 Chajes, Veronique
A1 Gunter, Marc J
A1 Murphy, Neil
K1 Breast cancer
K1 Diet
K1 Industrial trans fatty acids
K1 Ruminant trans fatty acids
AB Trans fatty acids (TFAs) have been hypothesised to influence breast cancer risk. However, relatively few prospective studies have examined this relationship, and well-powered analyses according to hormone receptor-defined molecular subtypes, menopausal status, and body size have rarely been conducted. In the European Prospective Investigation into Cancer and Nutrition (EPIC), we investigated the associations between dietary intakes of TFAs (industrial trans fatty acids [ITFAs] and ruminant trans fatty acids [RTFAs]) and breast cancer risk among 318,607 women. Multivariable hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards models, adjusted for other breast cancer risk factors. After a median follow-up of 8.1 years, 13,241 breast cancer cases occurred. In the multivariable-adjusted model, higher total ITFA intake was associated with elevated breast cancer risk (HR for highest vs lowest quintile, 1.14, 95% CI 1.06-1.23; P trend = 0.001). A similar positive association was found between intake of elaidic acid, the predominant ITFA, and breast cancer risk (HR for highest vs lowest quintile, 1.14, 95% CI 1.06-1.23; P trend = 0.001). Intake of total RTFAs was also associated with higher breast cancer risk (HR for highest vs lowest quintile, 1.09, 95% CI 1.01-1.17; P trend = 0.015). For individual RTFAs, we found positive associations with breast cancer risk for dietary intakes of two strongly correlated fatty acids (Spearman correlation r = 0.77), conjugated linoleic acid (HR for highest vs lowest quintile, 1.11, 95% CI 1.03-1.20; P trend = 0.001) and palmitelaidic acid (HR for highest vs lowest quintile, 1.08, 95% CI 1.01-1.16; P trend = 0.028). Similar associations were found for total ITFAs and RTFAs with breast cancer risk according to menopausal status, body mass index, and breast cancer subtypes. These results support the hypothesis that higher dietary intakes of ITFAs, in particular elaidic acid, are associated with elevated breast cancer risk. Due to the high correlation between conjugated linoleic acid and palmitelaidic acid, we were unable to disentangle the positive associations found for these fatty acids with breast cancer risk. Further mechanistic studies are needed to identify biological pathways that may underlie these associations.
PB BioMed Central Ltd.
YR 2021
FD 2021-02-25
LK http://hdl.handle.net/10668/17421
UL http://hdl.handle.net/10668/17421
LA en
NO Matta M, Huybrechts I, Biessy C, Casagrande C, Yammine S, Fournier A, et al. Dietary intake of trans fatty acids and breast cancer risk in 9 European countries. BMC Med. 2021 Mar 30;19(1):81.
DS RISalud
RD Apr 13, 2025