TY - JOUR AU - Perez-Del Palacio, Jose AU - Diaz, Caridad AU - Vergara, Noemi AU - Algieri, Francesca AU - Rodriguez-Nogales, Alba AU - de Pedro, Nuria AU - Rodriguez-Cabezas, M Elena AU - Genilloud, Olga AU - Galvez, Julio AU - Vicente, Francisca PY - 2017 DO - 10.3389/fphar.2017.00202 SN - 1663-9812 UR - http://hdl.handle.net/10668/11137 T2 - Frontiers in pharmacology AB - Nitric-oxide synthase, the enzyme responsible for mammalian nitric oxide generation, and cytochrome P450, the major enzymes involved in drug metabolism, share striking similarities. Therefore, it makes sense that cytochrome P450 drug mediated... LA - en PB - Frontiers Research Foundation KW - Drug metabolism KW - Immunomodulation KW - Nitric KW - Oxide CYP450 KW - Roxithromycin KW - Nitric oxide KW - Microsomes, liver KW - Macrolides KW - Nitric oxide synthase KW - Biotransformation KW - Macrophages TI - Exploring the Role of CYP3A4 Mediated Drug Metabolism in the Pharmacological Modulation of Nitric Oxide Production. TY - research article VL - 8 ER -