RT Journal Article
T1 Monochorionic diamniotic in vitro fertilization twins have a decreased incidence of twin-to-twin transfusion syndrome.
A1 Ben-Ami, Ido
A1 Molina, Francisca Sonia
A1 Battino, Shlomo
A1 Daniel-Spiegel, Etty
A1 Melcer, Yaakov
A1 Flöck, Anne
A1 Geipel, Annegret
A1 Odeh, Marwan
A1 Miron, Pierre
A1 Maymon, Ron
K1 IVF
K1 TTTS
K1 incidence
K1 monozygosity
K1 twins
AB To compare the incidence of twin-to-twin transfusion syndrome (TTTS) in spontaneous versus IVF-conceived twin pregnancies. Retrospective multicenter study. University-affiliated tertiary medical centers. Women admitted for 11-14 week's scan between January 1997 and July 2013 who were diagnosed with monochorionic (MC) diamniotic twin pregnancies. None. Mode of conception, TTTS. The study cohort included 327 pregnant women with live MC diamniotic twins. Of them, 284 (86.9%) and 43 (13.1%) were spontaneous and IVF conceived, respectively. The mean maternal age was significantly higher in IVF compared with in spontaneously conceived pregnancies (33.8 ± 5.5 vs. 31.6 ± 5.4, respectively). Thirty-seven twins (11.3%) had TTTS, of whom 36/284 (12.7%) versus 1/43 (2.3%) were spontaneously and IVF conceived, respectively. The mean week of delivery was significantly lower in MC twins diagnosed with TTTS compared with those without TTTS (32.7 ± 3.3 vs. 35.5 ± 2.5, respectively). Furthermore, there was a significantly higher birthweight discordancy in twins diagnosed with TTTS compared with those without (20.6% vs. 11%, respectively). The significantly lower proportion of TTTS found in IVF-conceived twins may suggest a different embryological process that lies at the core of IVF conception of monozygotic twinning.
YR 2015
FD 2015-12-12
LK http://hdl.handle.net/10668/9674
UL http://hdl.handle.net/10668/9674
LA en
DS RISalud
RD Apr 20, 2025