RT Journal Article T1 Unification of Treatments and Interventions for Tinnitus Patients (UNITI): a study protocol for a multi-center randomized clinical trial A1 Schoisswohl, Stefan A1 Langguth, Berthold A1 Schecklmann, Martin A1 Bernal-Robledano, Alberto A1 Boecking, Benjamin A1 Cederroth, Christopher R. A1 Chalanouli, Dimitra A1 Cima, Rilana A1 Denys, Sam A1 Dettling-Papargyris, Juliane A1 Escalera-Balsera, Alba A1 Espinosa-Sanchez, Juan Manuel A1 Gallego-Martinez, Alvaro A1 Giannopoulou, Efi A1 Hidalgo-Lopez, Leyre A1 Hummel, Michael A1 Kikidis, Dimitris A1 Koller, Michael A1 Lopez-Escamez, Jose A. A1 Marcrum, Steven C. A1 Markatos, Nikolaos A1 Martin-Lagos, Juan A1 Martinez-Martinez, Maria A1 Martinez-Martinez, Marta A1 Mata Ferron, Maria A1 Mazurek, Birgit A1 Mueller-Locatelli, Nicolas A1 Neff, Patrick A1 Oppel, Kevin A1 Perez-Carpena, Patricia A1 Robles-Bolivar, Paula A1 Rose, Matthias A1 Schiele, Tabea A1 Schiller, Axel A1 Simoes, Jorge A1 Stark, Sabine A1 Staudinger, Susanne A1 Stege, Alexandra A1 Verhaert, Nicolas A1 Schlee, Winfried K1 Tinnitus K1 Treatment K1 Hearing aids K1 Cognitive behavioral therapy K1 Sound therapy K1 Structured counseling K1 Multi-center K1 RCT K1 Acúfeno K1 Terapéutica K1 Audífonos K1 Terapia cognitivo-conductual K1 Terapia de sonidos K1 Ensayos clínicos controlados no aleatorios como asunto K1 Consejo AB Tinnitus represents a relatively common condition in the global population accompanied by various comorbidities and severe burden in many cases. Nevertheless, there is currently no general treatment or cure, presumable due to the heterogeneity of tinnitus with its wide variety of etiologies and tinnitus phenotypes. Hence, most treatment studies merely demonstrated improvement in a subgroup of tinnitus patients. The majority of studies are characterized by small sample sizes, unstandardized treatments and assessments, or applications of interventions targeting only a single organ level. Combinatory treatment approaches, potentially targeting multiple systems as well as treatment personalization, might provide remedy and enhance treatment responses. The aim of the present study is to systematically examine established tinnitus therapies both alone and in combination in a large sample of tinnitus patients. Further, it wants to provide the basis for personalized treatment approaches by evaluating a specific decision support system developed as part of an EU-funded collaborative project (Unification of treatments and interventions for tinnitus patients; UNITI project). PB BioMed Central YR 2021 FD 2021-12-04 LK http://hdl.handle.net/10668/4032 UL http://hdl.handle.net/10668/4032 LA en NO Schoisswohl S, Langguth B, Schecklmann M, Bernal-Robledano A, Boecking B, Cederroth CR, Chalanouli D, Cima R, Denys S, Dettling-Papargyris J, Escalera-Balsera A, Espinosa-Sanchez JM, Gallego-Martinez A, Giannopoulou E, Hidalgo-Lopez L, Hummel M, Kikidis D, Koller M, Lopez-Escamez JA, Marcrum SC, Markatos N, Martin-Lagos J, Martinez-Martinez M, Martinez-Martinez M, Ferron MM, Mazurek B, Mueller-Locatelli N, Neff P, Oppel K, Perez-Carpena P, Robles-Bolivar P, Rose M, Schiele T, Schiller A, Simoes J, Stark S, Staudinger S, Stege A, Verhaert N, Schlee W. Unification of Treatments and Interventions for Tinnitus Patients (UNITI): a study protocol for a multi-center randomized clinical trial. Trials. 2021 Dec 4;22(1):875 DS RISalud RD Apr 9, 2025