RT Journal Article
T1 Dynamical properties of feedback signalling in B lymphopoiesis: A mathematical modelling approach.
A1 Chulian, Salvador
A1 Martinez-Rubio, Alvaro
A1 Marciniak-Czochra, Anna
A1 Stiehl, Thomas
A1 Goñi, Cristina Blazquez
A1 Rodriguez Gutierrez, Juan Francisco
A1 Ramirez Orellana, Manuel
A1 Castillo Robleda, Ana
A1 Perez-Garcia, Victor M
A1 Rosa, Maria
K1 Haematopoiesis
K1 Lymphopoiesis
K1 Mathematical medicine
K1 Mathematical modelling
K1 Área de Gestión Sanitaria de Jerez, Costa Noroeste y Sierra de Cádiz
AB Haematopoiesis is the process of generation of blood cells. Lymphopoiesis generates lymphocytes, the cells in charge of the adaptive immune response. Disruptions of this process are associated with diseases like leukaemia, which is especially incident in children. The characteristics of self-regulation of this process make them suitable for a mathematical study. In this paper we develop mathematical models of lymphopoiesis using currently available data. We do this by drawing inspiration from existing structured models of cell lineage development and integrating them with paediatric bone marrow data, with special focus on regulatory mechanisms. A formal analysis of the models is carried out, giving steady states and their stability conditions. We use this analysis to obtain biologically relevant regions of the parameter space and to understand the dynamical behaviour of B-cell renovation. Finally, we use numerical simulations to obtain further insight into the influence of proliferation and maturation rates on the reconstitution of the cells in the B line. We conclude that a model including feedback regulation of cell proliferation represents a biologically plausible depiction for B-cell reconstitution in bone marrow. Research into haematological disorders could benefit from a precise dynamical description of B lymphopoiesis.
PB Elsevier
YR 2021
FD 2021-03-19
LK http://hdl.handle.net/10668/17376
UL http://hdl.handle.net/10668/17376
LA en
NO Chulián S, Martínez-Rubio Á, Marciniak-Czochra A, Stiehl T, Goñi CB, Rodríguez Gutiérrez JF, et al. Dynamical properties of feedback signalling in B lymphopoiesis: A mathematical modelling approach. J Theor Biol. 2021 Aug 7;522:110685
NO The support of the Junta de Andaluc´ıa group FQM-201 is gratefully acknowledged. This work has been partially supported by the Fundaci´on Española para la Ciencia y la Tecnología (FECYT, project PR214 from the University of Cádiz) and the Asociación Pablo Ugarte (APU). This work has been partially supported by the Junta de Comunidades de Castilla-La Mancha (grant number 395 SBPLY/17/180501/000154).
DS RISalud
RD Aug 16, 2025