RT Journal Article
T1 Inflammation and oxidative stress, the links between obesity and COVID-19: a narrative review.
A1 Moreno-Fernandez, Jorge
A1 Ochoa, Julio
A1 Ojeda, Maria Luisa
A1 Nogales, Fatima
A1 Carreras, Olimpia
A1 Diaz-Castro, Javier
K1 Body mass index
K1 COVID-19
K1 Immunity
K1 Inflammation
K1 Nutrition
K1 Obesity
K1 Oxidative stress
AB COVID-19, an acute respiratory disease caused by SARS-CoV-2, has rapidly become a pandemic. On the other hand, obesity is also reaching dramatic dimensions and it is a risk factor for morbidity and premature mortality. Obesity has been linked to a high risk of serious-associated complications to COVID-19, due to the increased risk of concomitant chronic diseases, which highlights the health public relevance of the topic. Obese subjects have a pro-inflammatory environment, which can further exacerbate COVID-19-induced inflammation and oxidative stress, explaining the increased risk of serious complications in these patients. Another factor that favors infection in obese patients is the high expression of ACE2 receptors in the adipose tissue. The negative impact of COVID-19 in obesity is also associated with a decrease in respiratory function, the concurrence of multiple comorbidities, a low-degree chronic inflammatory state, immunocompromised situation, and therefore a higher rate of hospitalization, mechanical ventilation, in-hospital complications such as pneumonia, and death. In this review, the link between obesity and COVID-19 was analyzed, exploring the potential common mechanisms in both diseases, with special attention to oxidative stress and inflammation, due to the crucial role of both pathways in the development of the disease.
PB Springer Dordrecht
YR 2022
FD 2022-03-03
LK http://hdl.handle.net/10668/21341
UL http://hdl.handle.net/10668/21341
LA en
NO Moreno-Fernandez J, Ochoa J, Ojeda ML, Nogales F, Carreras O, Díaz-Castro J. Inflammation and oxidative stress, the links between obesity and COVID-19: a narrative review. J Physiol Biochem. 2022 Aug;78(3):581-591.
DS RISalud
RD Apr 18, 2025