RT Journal Article
T1 Alternative Anaphylactic Routes: The Potential Role of Macrophages.
A1 Escribese, Maria M
A1 Rosace, Domenico
A1 Chivato, Tomas
A1 Fernandez, Tahia D
A1 Corbi, Angel L
A1 Barber, Domingo
K1 IgE
K1 IgG
K1 Anaphylaxis
K1 Macrophages
K1 Serotonin
AB Anaphylaxis is an acute, life-threatening, multisystem syndrome resulting from the sudden release of mediators from effector cells. There are two potential pathways for anaphylaxis. The first one, IgE-dependent anaphylaxis, is induced by antigen (Ag) cross-linking of Ag-specific IgE bound to the high-affinity IgE receptor (FcεRI) on mast cells and basophils. The second one, IgG-dependent anaphylaxis is induced by Ag cross-linking of Ag-specific IgG bound to IgG receptors (FcγRI, FcγRIIA, FcγRIIB, FcγRIIC, and FcγRIIIA) on macrophages, neutrophils, and basophils. Macrophages exhibit a huge functional plasticity and are capable of exerting their scavenging, bactericidal, and regulatory functions under a wide variety of tissue conditions. Herein, we will review their potential role in the triggering and development of anaphylaxis. Thereby, macrophages, among other immune cells, play a role in both anaphylactic pathways (1) by responding to anaphylactic mediators secreted by mast cells after specific IgE cross-linking or (2) by acting as effector cells in the anaphylactic response mediated by IgG. In this review, we will go over the cellular and molecular mechanisms that take place in the above-mentioned anaphylactic pathways and will discuss the clinical implications in human allergic reactions.
PB Frontiers Reseach Foundation
SN 1664-3224
YR 2017
FD 2017-05-08
LK http://hdl.handle.net/10668/11219
UL http://hdl.handle.net/10668/11219
LA en
NO Escribese MM, Rosace D, Chivato T, Fernández TD, Corbí AL, Barber D. Alternative Anaphylactic Routes: The Potential Role of Macrophages. Front Immunol. 2017 May 8;8:515
NO This work was supported by ISCIII (project numbers PI16/00249 and PI15/02256) cofunded by FEDER for the thematic network and cooperative research centers ARADyAL RD16/0006/0015 and RD16/0006/0001. This work was also supported by the Ministry of Economy and Competitiveness (project number SAF2014-52423-R) and by Fundación Mutua Madrileña (AP15891-2015). DR was supported by FPI-CEU predoctoral fellowships.
DS RISalud
RD Apr 10, 2025