RT Journal Article
T1 Cold-Induced Thermogenesis Shows a Diurnal Variation That Unfolds Differently in Males and Females.
A1 Straat, Maaike E
A1 Martinez-Tellez, Borja
A1 Sardjoe Mishre, Aashley
A1 Verkleij, Magdalena M A
A1 Kemmeren, Mirjam
A1 Pelsma, Iris C M
A1 Alcantara, Juan M A
A1 Mendez-Gutierrez, Andrea
A1 Kooijman, Sander
A1 Boon, Mariëtte R
A1 Rensen, Patrick C N
K1 brown adipose tissue
K1 cardiometabolic health
K1 circadian rhythm
K1 cold stimulus
K1 gender differences
K1 metabolism
AB Cold exposure mobilizes lipids to feed thermogenic processes in organs, including brown adipose tissue (BAT). In rodents, BAT metabolic activity exhibits a diurnal rhythm, which is highest at the start of the wakeful period. We investigated whether cold-induced thermogenesis displays diurnal variation in humans and differs between the sexes. This randomized crossover study included 24 young and lean male (n = 12) and female (n = 12) participants who underwent 2.5-hour personalized cooling using water-perfused mattresses in the morning (7:45 am) and evening (7:45 pm), with 1 day in between. We measured energy expenditure (EE) and supraclavicular skin temperature in response to cold exposure. In males, cold-induced EE was higher in the morning than in the evening (+54% ± 10% vs +30% ± 7%; P = 0.05) but did not differ between morning and evening in females (+37% ± 9% vs +30% ± 10%; P = 0.42). Only in males, supraclavicular skin temperature upon cold increased more in morning than evening (+0.2 ± 0.1 °C vs -0.2 ± 0.2 °C; P = 0.05). In males, circulating free fatty acid (FFA) levels were increased after morning cold exposure, but not evening (+90% ± 18% vs +9% ± 8%; P  Cold-induced thermogenesis is higher in morning than evening in males; however, lipid metabolism is more modulated in the morning than the evening in females.
PB Oxford University Press
YR 2022
FD 2022-02-18
LK http://hdl.handle.net/10668/20392
UL http://hdl.handle.net/10668/20392
LA en
NO Straat ME, Martinez-Tellez B, Sardjoe Mishre A, Verkleij MMA, Kemmeren M, Pelsma ICM, et al. Cold-Induced Thermogenesis Shows a Diurnal Variation That Unfolds Differently in Males and Females. J Clin Endocrinol Metab. 2022 May 17;107(6):1626-1635.
DS RISalud
RD Apr 11, 2025