RT Journal Article
T1 Cut-off value of D. pteronyssinus specific IgE in double negative patients Der p 1 and Der p 2 and its clinical repercussion
A1 Letrán, Antonio
A1 García, Ignacio
A1 Espinazo-Romeu, Marisa
A1 Moreno-Aguilar, Carmen
A1 Moreno, Francisco
K1 Dermatophagoides pteronyssinus
K1 Immunoglobulin E
K1 Asthma
K1 Rhinitis
K1 Antigens, Dermatophagoides
K1 Immunotherapy
K1 Inmunoglobulina E
K1 Asma
K1 Rinitis
K1 Antígenos dermatofagoides
K1 Inmunoterapia
K1 Pyroglyphidae
AB Accessibility to more precise diagnostic techniques such as component resolved diagnostics (CRD), provides us with an important advance in diagnostic aspects as well as treatment. The subject of this study aims to better understand the profiles of sensitization to Der p 1, Der p 2 and Der p 23 and to know to what extent their use could help us in optimizing the decision-making for their treatment with Specific Immunotherapy. Cross-sectional study of subjects older than 5 years, diagnosed with allergy to HDM using skin prick test and sIgE, with symptoms of rhinitis and/or asthma. Total and specific IgE was determined to D. pteronyssinus, nDer p 1, rDer p 2 and rDer p 23 using ImmunoCAP. 240 patients were recruited (97.1% rhinitis and 46.25% rhinitis and asthma). Four different phenotypes were observed: positive or negative for sIgE nDer p 1 and/or IgE rDer p 2. 17% of these patients sIgE were double negative for Der p 1 and Der p 2 (increasing with age and with significantly lower sIgE levels than the rest of the groups). Using ROC curves, value less than 2.18 KUA/L for D. pteronyssinus sIgE gave us a sensitivity and specificity of 0.882 and 0.985, respectively, to double negative IgE nDer p 1 and IgE rDer p 2 group. Despite positive SPT and sIgE to D. pteronyssinus, 17% of the studied population is IgE nDer p 1 and IgE rDer p 2 double negative, with a cut-off value of 2.18 KU/L, which is very relevant for taking of decisions in prescription of AIT. The double positive population sIgE nDer p 1 and IgE rDer p 2 is associated with asthma compared to the other groups and this does not seem to be influenced by IgE rDer p 23.
PB Springer Nature
YR 2021
FD 2021-12-08
LK http://hdl.handle.net/10668/4477
UL http://hdl.handle.net/10668/4477
LA en
NO Letrán A, García I, Espinazo-Romeu M, Moreno-Aguilar C, Moreno F. Cut-off value of D. pteronyssinus specific IgE in double negative patients Der p 1 and Der p 2 and its clinical repercussion. Sci Rep. 2021 Dec 8;11(1):23585
DS RISalud
RD Apr 5, 2025