TY - JOUR AU - Kern, Fabian AU - Krammes, Lena AU - Danz, Karin AU - Diener, Caroline AU - Kehl, Tim AU - Küchler, Oliver AU - Fehlmann, Tobias AU - Kahraman, Mustafa AU - Rheinheimer, Stefanie AU - Aparicio-Puerta, Ernesto AU - Wagner, Sylvia AU - Ludwig, Nicole AU - Backes, Christina AU - Lenhof, Hans-Peter AU - von Briesen, Hagen AU - Hart, Martin AU - Keller, Andreas AU - Meese, Eckart PY - 2020 DO - 10.1093/nar/gkaa1161 UR - http://hdl.handle.net/10668/16774 T2 - Nucleic acids research AB - MicroRNAs are regulators of gene expression. A wide-spread, yet not validated, assumption is that the targetome of miRNAs is non-randomly distributed across the transcriptome and that targets share functional pathways. We developed a computational and... LA - en PB - Oxford University Press KW - Cell Line KW - Genes, Reporter KW - Mesencephalon KW - Neurons KW - Sensitivity and Specificity KW - Transforming Growth Factor beta KW - 1-Methyl-4-phenylpyridinium KW - 3' Untranslated Regions KW - Cell Line, Tumor KW - Gene Expression Regulation KW - High-Throughput Screening Assays KW - Humans KW - MicroRNAs KW - Neuroblastoma KW - Parkinson Disease KW - Predictive Value of Tests KW - Signal Transduction KW - Transcriptome KW - Tumor Necrosis Factor-alpha TI - Validation of human microRNA target pathways enables evaluation of target prediction tools. TY - research article VL - 49 ER -