RT Journal Article
T1 The Genetics of Drug Hypersensitivity Reactions.
A1 Cornejo-García, J A
A1 Jurado-Escobar, R
A1 Doña, I
A1 Perkins, J R
A1 Agúndez, J A
A1 García-Martín, E
A1 Viguera, E
A1 Blanca-López, N
A1 Canto, G
A1 Blanca, M
K1 Cross-intolerance
K1 Drug hypersensitivity
K1 Genome-wide association study
K1 Immediate and nonimmediate reactions
K1 Single-nucleotide polymorphisms
AB DHRs are induced by various mechanisms and encompass a heterogeneous set of potentially life-threatening clinical entities. In addition to environmental effects, individual factors play a key role in this intricate puzzle. However, despite commendable efforts in recent years to identify individual predisposing factors, our knowledge of the genetic basis of these reactions remains incomplete. In this manuscript, we summarize current research on the genetics of DHRs, focusing on specific immune-mediated reactions (immediate and nonimmediate) and on pharmacologically mediated reactions (cross-intolerance to nonsteroidal anti-inflammatory drugs). We also provide some thoughts on potential technological approaches that would help us to decipher the molecular mechanisms underlying DHRs. We believe this manuscript will be of interest not only for allergists and basic researchers in the field, but also for clinicians from various areas of expertise who manage these reactions in their clinical practice.
SN 1018-9068
YR 2016
FD 2016-06-30
LK http://hdl.handle.net/10668/10237
UL http://hdl.handle.net/10668/10237
LA en
DS RISalud
RD Apr 19, 2025