RT Journal Article
T1 The cargo protein MAP17 (PDZK1IP1) regulates the immune microenvironment
A1 Garcia-Heredia, Jose M.
A1 Carnero, Amancio
K1 MAP17
K1 oncogene
K1 inflammation
K1 cancer
K1 inflammatory diseases
K1 Inflammatory-bowel-disease
K1 Cancer-related inflammation
K1 Proteasome inhibitor bortezomib
K1 Cd8(+) t-cells
K1 Mhc class-i
K1 Transcription factor
K1 Crohns-disease
K1 Ulcerative-colitis
K1 Epithelial-cells
K1 Human carcinomas
AB Inflammation is a complex defensive response activated after various harmful stimuli allowing the clearance of damaged cells and initiating healing and regenerative processes. Chronic, or pathological, inflammation is also one of the causes of neoplastic transformation and cancer development. MAP17 is a cargo protein that transports membrane proteins from the endoplasmic reticulum. Therefore, its overexpression may be linked to an excess of membrane proteins that may be recognized as an unwanted signal, triggering local inflammation. Therefore, we analyzed whether its overexpression is related to an inflammatory phenotype. In this work, we found a correlation between MAP17 expression and inflammatory phenotype in tumors and in other inflammatory diseases such as Crohn's disease, Barrett's esophagus, COPD or psoriasis. MAP17 expression correlated also with the markers of inflammation HLAs, BBS10, HERC2, ADNP and PYCARD. Furthermore, we found that MAP17 expression directly regulates NFAT2 and IL-6 activation, inducing the differentiation of monocytes to dendritic cells and suggesting a causal role of MAP17 in inflammation. Immunohistochemistry confirms local inflammation, mainly CD45(+) cells, at the site of expression of MAP17, at least in tumors, Crohn's and psoriasis. Therefore, our data indicates that the overexpression of the protein MAP17 plays important role in diseases involving chronic inflammation.
PB Impact journals llc
YR 2017
FD 2017-11-17
LK http://hdl.handle.net/10668/19444
UL http://hdl.handle.net/10668/19444
LA en
DS RISalud
RD Apr 6, 2025