TY - JOUR AU - Castosa, Raquel AU - Martinez-Iglesias, Olaia AU - Roca-Lema, Daniel AU - Casas-Pais, Alba AU - Díaz-Díaz, Andrea AU - Iglesias, Pilar AU - Santamarina, Isabel AU - Graña, Begoña AU - Calvo, Lourdes AU - Valladares-Ayerbes, Manuel AU - Concha, Ángel AU - Figueroa, Angélica PY - 2018 DO - 10.1038/s41598-018-21808-w UR - http://hdl.handle.net/10668/12171 T2 - Scientific reports AB - At early stages of carcinoma progression, epithelial cells undergo a program named epithelial-to-mesenchymal transition characterized by the loss of the major component of the adherens junctions, E-cadherin, which in consequence causes the disruption... LA - en KW - Adenocarcinoma KW - Animals KW - Cadherins KW - Carcinogenesis KW - Cell Line, Tumor KW - Cell Proliferation KW - Colonic Neoplasms KW - Dogs KW - Female KW - Gene Expression Regulation, Neoplastic KW - Humans KW - Lung Neoplasms KW - Madin Darby Canine Kidney Cells KW - Male KW - Mice KW - Neoplasm Invasiveness KW - Neoplasm Staging KW - Ubiquitin-Protein Ligases KW - Xenograft Model Antitumor Assays TI - Hakai overexpression effectively induces tumour progression and metastasis in vivo. TY - research article VL - 8 ER -