RT Journal Article
T1 Striatal GDNF Production Is Independent to Circulating Estradiol Level Despite Pan-Neuronal Activation in the Female Mouse.
A1 Enterria-Morales, Daniel
A1 Lopez-Lopez, Ivette
A1 Lopez-Barneo, Jose
A1 d'Anglemont-de-Tassigny, Xavier
K1 Corpus Striatum
K1 Estradiol
K1 Glial Cell Line-Derived Neurotrophic Factor
K1 Parkinson Disease
K1 RNA, Messenger
AB Gender difference in Parkinson's disease (PD) suggests that female sex steroids may promote dopaminergic neuron survival and protect them from degeneration. The glial cell line-derived neurotrophic factor (GDNF) is believed to be dopaminotrophic; thus it is considered as a potential therapeutic target in PD. Additionally, GDNF is endogenously synthetized in the caudate/putamen of humans and striatum in rodents. A neuroprotective role of estrogens on the nigrostriatal pathway via the stimulation of GDNF has been proposed. Since the GDNF-producing parvalbumin (Parv) interneurons express the estrogen receptor alpha in the mouse striatum, we sought to determine whether ectopic estrogenic compound modulates the GDNF synthesis in mice. Using an ovariectomized-estradiol (E2) replacement regimen, which reliably generates a rise of plasma estradiol, we assessed the effects of different levels of E2 on the activation of striatal neuronal populations, and GDNF production. A strong correlation was found between plasma E2 and the expression of the immediate early gene cFos in the striatum, as well as in other cortical regions. However, moderate and high E2 treatments failed to induce any striatal GDNF mRNA and protein synthesis. High E2 only stimulates cFos induction in a low percentage of striatal Parv neurons whereas the majority of cFos-positive cells are medium spiny neurons. Activation of these projecting neurons by E2 suggests a role of circulating sex steroids in the modulation of striatal neural pathways.
PB Public Library of Science
YR 2016
FD 2016-10-14
LK http://hdl.handle.net/10668/10535
UL http://hdl.handle.net/10668/10535
LA en
NO Enterría-Morales D, López-López I, López-Barneo J, d'Anglemont de Tassigny X. Striatal GDNF Production Is Independent to Circulating Estradiol Level Despite Pan-Neuronal Activation in the Female Mouse. PLoS One. 2016 Oct 14;11(10):e0164391.
DS RISalud
RD Sep 19, 2025