RT Journal Article
T1 Assessment of Waldeyer's ring in pediatric and adolescent Hodgkin lymphoma patients-Importance of multimodality imaging: Results from the EuroNet-PHL-C1 trial.
A1 Kurch, Lars
A1 Mauz-Körholz, Christine
A1 Fosså, Alexander
A1 Georgi, Thomas Walther
A1 Kluge, Regine
A1 Bartelt, Jörg Martin
A1 Kunze, Christian
A1 Wohlgemuth, Walter Alexander
A1 Pelz, Tanja
A1 Vordermark, Dirk
A1 Plößl, Sebastian
A1 Hasenclever, Dirk
A1 Sabri, Osama
A1 Landman-Parker, Judith
A1 Wallace, William Hamish
A1 Karlen, Jonas
A1 Fernández-Teijeiro, Ana
A1 Cepelova, Michaela
A1 Klekawka, Tomasz
A1 Løndalen, Ayca Muftuler
A1 Steiner, Dagmar
A1 Krombach, Gabriele
A1 Attarbaschi, Andishe
A1 Hoffmann, Martha
A1 Ceppi, Francesco
A1 Pears, Jane
A1 Hraskova, Andrea
A1 Uyttebroeck, Anne
A1 Beishuizen, Auke
A1 Dieckmann, Karin
A1 Leblanc, Thierry
A1 Daw, Stephen
A1 Körholz, Dieter
A1 Stoevesandt, Dietrich
K1 18F-FDG-PET
K1 CT
K1 ENT investigation
K1 MRI
K1 Waldeyer's ring
K1 multimodality imaging
K1 pediatric Hodgkin lymphoma
K1 staging
AB In the EuroNet Pediatric Hodgkin Lymphoma (EuroNet-PHL) trials, decision on Waldeyer's ring (WR) involvement is usually based on clinical assessment, that is, physical examination and/or nasopharyngoscopy. However, clinical assessment only evaluates mucosal surface and is prone to interobserver variability. Modern cross-sectional imaging technology may provide valuable information beyond mucosal surface, which may lead to a more accurate WR staging. The EuroNet-PHL-C1 trial recruited 2102 patients, of which 1752 underwent central review including reference reading of their cross-sectional imaging data. In 14 of 1752 patients, WR was considered involved according to clinical assessment. In these 14 patients, the WR was re-assessed by applying an imaging-based algorithm considering information from 18 F-fluorodeoxyglucose positron emission tomography, contrast-enhanced computed tomography, and/or magnetic resonance imaging. For verification purposes, the imaging-based algorithm was applied to 100 consecutive patients whose WR was inconspicuous on clinical assessment. The imaging-based algorithm confirmed WR involvement only in four of the 14 patients. Of the remaining 10 patients, four had retropharyngeal lymph node involvement and six an inconspicuous WR. Applying the imaging-based algorithm to 100 consecutive patients with physiological appearance of their WR on clinical assessment, absence of WR involvement could be confirmed in 99. However, suspicion of WR involvement was raised in one patient. The imaging-based algorithm was feasible and easily applicable at initial staging of young patients with Hodgkin lymphoma. It increased the accuracy of WR staging, which may contribute to a more individualized treatment in the future.
YR 2021
FD 2021-02-03
LK http://hdl.handle.net/10668/17101
UL http://hdl.handle.net/10668/17101
LA en
DS RISalud
RD Apr 20, 2025