RT Journal Article
T1 Liraglutide Improves Forced Vital Capacity in Individuals With Type 2 Diabetes: Data From the Randomized Crossover LIRALUNG Study.
A1 Lopez-Cano, Carolina
A1 Ciudin, Andreea
A1 Sanchez, Enric
A1 Tinahones, Francisco J
A1 Barbe, Ferran
A1 Dalmases, Mireia
A1 Garcia-Ramirez, Marta
A1 Soto, Alfonso
A1 Gaeta, Anna Michela
A1 Pellitero, Silvia
A1 Marti, Raquel
A1 Hernandez, Cristina
A1 Simo, Rafael
A1 Lecube, Albert
AB To evaluate the effect of liraglutide, a glucagon-like peptide 1 receptor agonist, on pulmonary function and serum levels of surfactant protein D (SP-D) in type 2 diabetes. A double-blind, randomized, crossover, placebo-controlled clinical trial comprising 76 patients with a baseline forced expiratory volume in 1 s<90% of that predicted. Liraglutide was administered for 7 weeks (2 weeks of titration plus 5 weeks at 1.8 mg daily). This short duration was intentional to minimize weight loss as a potential confounding factor. Serum level of SP-D was used as a biomarker of alveolar-capillary barrier integrity. Liraglutide exerted a positive impact on forced vital capacity (FVC) in comparison with placebo (DFVC 5.2% of predicted [from 0.8 to 9.6]; P 5 0.009). No differences in the other pulmonary variables were observed. Participants under liraglutide treatment also experienced a decrease in serum SP-D (P 5 0.038). The absolute change in FVC correlated with final serum SP-D in participants receiving liraglutide (r 5 20.313, P 5 0.036). Stepwise multivariate regression analysis showed that f inal serum SP-D independently predicted changes in FVC. In conclusion, liraglutide increased FVC in patients with type 2 diabetes. This effect was associated with a significant decrease of circulating SP-D, thus pointing to abeneficial effect in the alveolar-capillary function.
PB American Diabetes Association
YR 2022
FD 2022-11-01
LK http://hdl.handle.net/10668/20499
UL http://hdl.handle.net/10668/20499
LA en
NO López-Cano C, Ciudin A, Sánchez E, Tinahones FJ, Barbé F, Dalmases M, et al. Liraglutide Improves Forced Vital Capacity in Individuals With Type 2 Diabetes: Data From the Randomized Crossover LIRALUNG Study. Diabetes. 2022 Feb 1;71(2):315-320
DS RISalud
RD Aug 3, 2025