%0 Journal Article
%A Lopez-Cano, Carolina
%A Ciudin, Andreea
%A Sanchez, Enric
%A Tinahones, Francisco J
%A Barbe, Ferran
%A Dalmases, Mireia
%A Garcia-Ramirez, Marta
%A Soto, Alfonso
%A Gaeta, Anna Michela
%A Pellitero, Silvia
%A Marti, Raquel
%A Hernandez, Cristina
%A Simo, Rafael
%A Lecube, Albert
%T Liraglutide Improves Forced Vital Capacity in Individuals With Type 2 Diabetes: Data From the Randomized Crossover LIRALUNG Study.
%D 2022
%U http://hdl.handle.net/10668/20499
%X To evaluate the effect of liraglutide, a glucagon-like peptide 1 receptor agonist, on pulmonary function and serum levels of surfactant protein D (SP-D) in type 2 diabetes. A double-blind, randomized, crossover, placebo-controlled clinical trial comprising 76 patients with a baseline forced expiratory volume in 1 s<90% of that predicted. Liraglutide was administered for 7 weeks (2 weeks of titration plus 5 weeks at 1.8 mg daily). This short duration was intentional to minimize weight loss as a potential confounding factor. Serum level of SP-D was used as a biomarker of alveolar-capillary barrier integrity. Liraglutide exerted a positive impact on forced vital capacity (FVC) in comparison with placebo (DFVC 5.2% of predicted [from 0.8 to 9.6]; P 5 0.009). No differences in the other pulmonary variables were observed. Participants under liraglutide treatment also experienced a decrease in serum SP-D (P 5 0.038). The absolute change in FVC correlated with final serum SP-D in participants receiving liraglutide (r 5 20.313, P 5 0.036). Stepwise multivariate regression analysis showed that f inal serum SP-D independently predicted changes in FVC. In conclusion, liraglutide increased FVC in patients with type 2 diabetes. This effect was associated with a significant decrease of circulating SP-D, thus pointing to abeneficial effect in the alveolar-capillary function.
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