RT Journal Article
T1 COVID-19 pneumonia treated with ultra-low doses of radiotherapy (ULTRA-COVID study): a single institution report of two cases.
A1 Moreno-Olmedo, Elena
A1 Suárez-Gironzini, Vladimir
A1 Pérez, Manuel
A1 Filigheddu, Teresa
A1 Mínguez, Cristina
A1 Sanjuan-Sanjuan, Alba
A1 González, José A
A1 Rivas, Daniel
A1 Gorospe, Luis
A1 Larrea, Luis
A1 López, Escarlata
K1 COVID-19 pneumonitis
K1 Cytokine storm
K1 Inflamatory response
K1 Radiation
K1 SARS-CoV-2
AB Since the outbreak of coronavirus disease 2019 (COVID-19) pandemic, healthcare systems have focused their efforts into finding a treatment to avoid the fatal outcomes of severe acute respiratory syndrome due to coronavirus‑2 (SARS-CoV-2). Benefits and risks of systemic treatments remain unclear, with multiple clinical trials still ongoing. Radiotherapy could play a role in reducing the inflammatory response in the lungs and relieve life-threatening symptoms. We designed a prospective study of Ultra-Low Doses of Therapy with Radiation Applied to COVID-19 (ULTRA-COVID) for patients who suffer pneumonia, are not candidates for invasive mechanical ventilation and show no improvement with medical therapy. We present the preliminary results of two patients diagnosed with COVID-19 pneumonia treated with ULTRA-COVID. After one radiotherapy session, significant clinical response and a good radiological response was observed in both cases, resulting in both patients being discharged from hospital in less than 2 weeks after radiation treatment. Preliminary clinical and radiological results suggest a potential benefit of treating COVID-19 pneumonia with ULTRA-COVID. ClinicalTrials.gov Identifier: NCT04394182.
YR 2021
FD 2021-01-27
LK http://hdl.handle.net/10668/17057
UL http://hdl.handle.net/10668/17057
LA en
DS RISalud
RD Apr 13, 2025