%0 Journal Article
%A Moreno-Olmedo, Elena
%A Suárez-Gironzini, Vladimir
%A Pérez, Manuel
%A Filigheddu, Teresa
%A Mínguez, Cristina
%A Sanjuan-Sanjuan, Alba
%A González, José A
%A Rivas, Daniel
%A Gorospe, Luis
%A Larrea, Luis
%A López, Escarlata
%T COVID-19 pneumonia treated with ultra-low doses of radiotherapy (ULTRA-COVID study): a single institution report of two cases.
%D 2021
%U http://hdl.handle.net/10668/17057
%X Since the outbreak of coronavirus disease 2019 (COVID-19) pandemic, healthcare systems have focused their efforts into finding a treatment to avoid the fatal outcomes of severe acute respiratory syndrome due to coronavirus‑2 (SARS-CoV-2). Benefits and risks of systemic treatments remain unclear, with multiple clinical trials still ongoing. Radiotherapy could play a role in reducing the inflammatory response in the lungs and relieve life-threatening symptoms. We designed a prospective study of Ultra-Low Doses of Therapy with Radiation Applied to COVID-19 (ULTRA-COVID) for patients who suffer pneumonia, are not candidates for invasive mechanical ventilation and show no improvement with medical therapy. We present the preliminary results of two patients diagnosed with COVID-19 pneumonia treated with ULTRA-COVID. After one radiotherapy session, significant clinical response and a good radiological response was observed in both cases, resulting in both patients being discharged from hospital in less than 2 weeks after radiation treatment. Preliminary clinical and radiological results suggest a potential benefit of treating COVID-19 pneumonia with ULTRA-COVID. ClinicalTrials.gov Identifier: NCT04394182.
%K COVID-19 pneumonitis
%K Cytokine storm
%K Inflamatory response
%K Radiation
%K SARS-CoV-2
%~