RT Journal Article
T1 Impact of Cumulative Environmental and Dietary Xenobiotics on Human Microbiota: Risk Assessment for One Health.
A1 Ortiz, Pilar
A1 Torres-Sanchez, Alfonso
A1 Lopez-Moreno, Ana
A1 Cerk, Klara
A1 Ruiz-Moreno, Angel
A1 Monteoliva-Sanchez, Mercedes
A1 Ampatzoglou, Antonis
A1 Aguilera, Margarita
A1 Gruszecka-Kosowska, Agnieszka
K1 ADME approach
K1 farm to fork strategy
K1 microbiome
K1 risk assessment
K1 xenobiotic
AB Chemical risk assessment in the context of the risk analysis framework was initially designed to evaluate the impact of hazardous substances or xenobiotics on human health. As the need of multiple stressors assessment was revealed to be more reliable regarding the occurrence and severity of the adverse effects in the exposed organisms, the cumulative risk assessment started to be the recommended approach. As toxicant mixtures and their "cocktail effects" are considered to be main hazards, the most important exposure for these xenobiotics would be of dietary and environmental origin. In fact, even a more holistic prism should currently be considered. In this sense, the definition of One Health refers to simultaneous actions for improving human, animal, and environmental health through transdisciplinary cooperation. Global policies necessitate going beyond the classical risk assessment for guaranteeing human health through actions and implementation of the One Health approach. In this context, a new perspective is proposed for the integration of microbiome biomarkers and next generation probiotics potentially impacting and modulating not only human health, but plant, animal health, and the environment.
PB MDPI AG
YR 2022
FD 2022-03-10
LK http://hdl.handle.net/10668/21369
UL http://hdl.handle.net/10668/21369
LA en
NO Ortiz P, Torres-Sánchez A, López-Moreno A, Cerk K, Ruiz-Moreno Á, Monteoliva-Sánchez M, et al.  Impact of Cumulative Environmental and Dietary Xenobiotics on Human Microbiota: Risk Assessment for One Health. J Xenobiot. 2022 Mar 17;12(1):56-63.
DS RISalud
RD Apr 12, 2025